Sigma1 Receptor Antagonist BD1047 Enhances Reversal of Conditioned Place Preference from Cocaine to Social Interaction

被引：24

作者：

Fritz, Michael ^{[1
]}

Klement, Sabine ^{[1
]}

El Rawas, Rana ^{[1
]}

Saria, Alois ^{[1
]}

Zernig, Gerald ^{[1
]}

机构：

[1] Med Univ Innsbruck, Expt Psychiat Unit, AT-6020 Innsbruck, Austria

来源：

PHARMACOLOGY | 2011年 / 87卷 / 1-2期

基金：

奥地利科学基金会;

关键词：

Addiction; Cocaine; Conditioned place preference; Sigma1 receptor BD1047; Social interaction; Sprague Dawley rat; Substance dependence; Treatment adherence; INVOLVEMENT;

D O I：

10.1159/000322534

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We have previously shown that only four 15-min social interaction episodes with a male adult conspecific reversed cocaine conditioned place preference (CPP) even despite continuing CPP training with cocaine. In the present study, we investigated if BD1047, a sigma1 receptor antagonist that has been shown to inhibit the expression of cocaine CPP, is able to enhance this effect. BD1047, given as a 10-min pretreatment, dose-dependently (ED50 of 0.0036 mg/kg i.p.) decreased the time spent in the previously cocaine-associated compartment in favour of the time spent in the compartment in which a single social interaction had taken place. Our findings indicate that sigma1 blockade may be used therapeutically to enhance treatment adherence in social interaction-based rehabilitation programs. Copyright (C) 2010 S. Karger AG, Basel

引用

页码：45 / 48

页数：4

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