Leishmania and the macrophage: a multifaceted interaction

被引：151

作者：

Podinovskaia, Maria ^{[1
,2
]}

Descoteaux, Albert ^{[1
,2
]}

机构：

[1] INRS, Inst Armand Frappier, Laval, PQ H7V 1B7, Canada

[2] Ctr Host Parasite Interact, Laval, PQ H7V 1B7, Canada

来源：

FUTURE MICROBIOLOGY | 2015年 / 10卷 / 01期

基金：

加拿大自然科学与工程研究理事会;

关键词：

GP63; Leishmania; lipophosphoglycan; macrophage; phagocytosis; phagosome; ACTIVATED PROTEIN-KINASE; PARASITOPHOROUS VACUOLES; PHAGOSOMAL MATURATION; ANTIGEN PRESENTATION; CROSS-PRESENTATION; VIRULENCE FACTORS; HOST MACROPHAGES; OXIDATIVE BURST; DENDRITIC CELLS; NADPH OXIDASE;

D O I：

10.2217/fmb.14.103

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Leishmania, the causative agent of leishmaniases, is an intracellular parasite of macrophages, transmitted to humans via the bite of its sand fly vector. This protozoan organism has evolved strategies for efficient uptake into macrophages and is able to regulate phagosome maturation in order to make the phagosome more hospitable for parasite growth and to avoid destruction. As a result, macrophage defenses such as oxidative damage, antigen presentation, immune activation and apoptosis are compromised whereas nutrient availability is improved. Many Leishmania survival factors are involved in shaping the phagosome and reprogramming the macrophage to promote infection. This review details the complexity of the host-parasite interactions and summarizes our latest understanding of key events that make Leishmania such a successful intracellular parasite.

引用

页码：111 / 129

页数：19

共 107 条

[61] Lipid Body-Phagosome Interaction in Macrophages during Infectious Diseases: Host Defense or Pathogen Survival Strategy? [J].

Melo, Rossana C. N. ;

Dvorak, Ann M. .

PLOS PATHOGENS, 2012, 8 (07) :6

[62] Heme Uptake Mediated by LHR1 Is Essential for Leishmania amazonensis Virulence [J].

Miguel, Danilo C. ;

Flannery, Andrew R. ;

Mittra, Bidyottam ;

Andrews, Norma W. .

INFECTION AND IMMUNITY, 2013, 81 (10) :3620-3626

[63] IRONy OF FATE: role of iron-mediated ROS in Leishmania differentiation [J].

Mittra, Bidyottam ;

Andrews, Norma W. .

TRENDS IN PARASITOLOGY, 2013, 29 (10) :489-496

[64] Iron uptake controls the generation of Leishmania infective forms through regulation of ROS levels [J].

Mittra, Bidyottam ;

Cortez, Mauro ;

Haydock, Andrew ;

Ramasamy, Gowthaman ;

Myler, Peter J. ;

Andrews, Norma W. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2013, 210 (02) :401-416

[65] Selective Fusion of Azurophilic Granules with Leishmania-containing Phagosomes in Human Neutrophils [J].

Mollinedo, Faustino ;

Janssen, Hans ;

de la Iglesia-Vicente, Janis ;

Villa-Pulgarin, Janny A. ;

Calafat, Jero .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (45) :34528-34536

[66] Leishmania promastigotes: building a safe niche within macrophages [J].

Moradin, Neda ;

Descoteaux, Albert .

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2012, 2 :121

[67] The Leishmania-macrophage interaction:: a metabolic perspective [J].

Naderer, Thomas ;

McConville, Malcolm J. .

CELLULAR MICROBIOLOGY, 2008, 10 (02) :301-308

[68] Identification of leishmania fructose-1,6-bisphosphate aldolase as a novel activator of host macrophage Src homology 2 domain containing protein tyrosine phosphatase SHP-1 [J].

Nandan, Devki ;

Tran, Thao ;

Trinh, Eva ;

Silverman, Judith M. ;

Lopez, Martin .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 364 (03) :601-607

[69] Leishmania parasitophorous vacuoles interact continuously with the host cell's endoplasmic reticulum; parasitophorous vacuoles are hybrid compartments [J].

Ndjamen, Blaise ;

Kang, Byung-Ho ;

Hatsuzawa, Kiyotaka ;

Kima, Peter E. .

CELLULAR MICROBIOLOGY, 2010, 12 (10) :1480-1494

[70] Leishmania virulence factors: focus on the metalloprotease GP63 [J].

Olivier, Martin ;

Atayde, Vanessa Diniz ;

Isnard, Amandine ;

Hassani, Kasra ;

Shio, Marina Tiemi .

MICROBES AND INFECTION, 2012, 14 (15) :1377-1389

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