Leishmania and the macrophage: a multifaceted interaction

被引：151

作者：

Podinovskaia, Maria ^{[1
,2
]}

Descoteaux, Albert ^{[1
,2
]}

机构：

[1] INRS, Inst Armand Frappier, Laval, PQ H7V 1B7, Canada

[2] Ctr Host Parasite Interact, Laval, PQ H7V 1B7, Canada

来源：

FUTURE MICROBIOLOGY | 2015年 / 10卷 / 01期

基金：

加拿大自然科学与工程研究理事会;

关键词：

GP63; Leishmania; lipophosphoglycan; macrophage; phagocytosis; phagosome; ACTIVATED PROTEIN-KINASE; PARASITOPHOROUS VACUOLES; PHAGOSOMAL MATURATION; ANTIGEN PRESENTATION; CROSS-PRESENTATION; VIRULENCE FACTORS; HOST MACROPHAGES; OXIDATIVE BURST; DENDRITIC CELLS; NADPH OXIDASE;

D O I：

10.2217/fmb.14.103

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Leishmania, the causative agent of leishmaniases, is an intracellular parasite of macrophages, transmitted to humans via the bite of its sand fly vector. This protozoan organism has evolved strategies for efficient uptake into macrophages and is able to regulate phagosome maturation in order to make the phagosome more hospitable for parasite growth and to avoid destruction. As a result, macrophage defenses such as oxidative damage, antigen presentation, immune activation and apoptosis are compromised whereas nutrient availability is improved. Many Leishmania survival factors are involved in shaping the phagosome and reprogramming the macrophage to promote infection. This review details the complexity of the host-parasite interactions and summarizes our latest understanding of key events that make Leishmania such a successful intracellular parasite.

引用

页码：111 / 129

页数：19

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