SPECTROPHOTOMETRIC DETERMINATION OF P-AMINOPHENOL IN DRUGS USING 5,7-DICHLORO-4,6-DINITROBENZOFUROXAN REAGENT IN MICELLAR MEDIUM

被引：8

作者：

Bakeeva, R. F. ^{[1
]}

Gorbunova, T. S. ^{[1
]}

Vakhitova, O. E. ^{[1
]}

Gaisina, A. I. ^{[1
]}

Yusupova, L. M. ^{[1
]}

Garmonov, S. Yu. ^{[1
]}

Sopin, V. F. ^{[1
]}

机构：

[1] Kazan State Technol Univ, Kazan, Tatarstan, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2010年 / 44卷 / 05期

关键词：

p-aminophenol; drugs; spectrophotometry;

D O I：

10.1007/s11094-010-0450-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new spectrophotometric method for determining p-aminophenol in micellar aqueous dimethylsulfoxide (DMSO) media with non-ionogenic surfactant Triton X-100 that makes use of 5,7-dichloro-4,6-dinitrobenzofuroxan as an indicator has been developed. Using the proposed method, it is possible to detect an admixture of p-aminophenol in paracetamol (acetaminophen) in such media on a level that is much lower than the limiting concentration. The presence of Triton X-100 in the form of micelles improves the sensitivity of spectrophotometric determination compared to that of standard techniques.

引用

页码：282 / 286

页数：5