Mass spectrometry-coupled techniques for viral-related disease biomarker identification

被引：2
|
作者：
Rhea, Jeanne M. [1 ]
Diwan, Charbel A. [1 ]
Molinaro, Ross J. [1 ]
机构：
[1] Emory Univ, Sch Med, Dept Pathol & Lab Med, Atlanta, GA 30322 USA
来源：
BIOMARKERS IN MEDICINE | 2010年 / 4卷 / 06期
关键词：
cancer; infectious diseases; mass spectrometry; proteomics; viral biomarkers; VIRUS-RELATED VIRUS; 2-DIMENSIONAL GEL-ELECTROPHORESIS; LASER CAPTURE MICRODISSECTION; PROSTATE-CANCER; PROTEOMIC ANALYSIS; HEPATITIS-C; IMAGE REGISTRATION; PROTEIN EXPRESSION; BINDING-PROTEIN; CELLS;
D O I：
10.2217/BMM.10.110
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The advent of high-resolution mass spectrometers coupled with proteomic techniques has facilitated the discovery and characterization of novel viral proteins and the detection of virus-induced changes in the cellular proteome. These advances have enabled a more comprehensive characterization of viral interactions involved in infection and pathogenesis, and allowed the discovery of viral biomarkers. This article focuses on the role of mass spectrometry proteomic techniques to identify and characterize both prospective and verified viral biomarkers, and their implications on the diagnosis of disease.
引用
收藏
页码：859 / 870
页数：12
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