A partially degraded product of phytate suppresses the proliferation of HCT116 colorectal cancer cells

被引：7
作者：
Ishizuka, Satoshi [1 ]
Saitoh, Ken-ichi [1 ]
Suzuki, Takuya [1 ]
Lee, Jae-Sung [1 ]
Hara, Hiroshi [1 ]
机构：
[1] Hokkaido Univ, Res Fac Agr, Div Appl Biosci, Kita Ku, Sapporo, Hokkaido 0608589, Japan
来源：
FOOD CHEMISTRY | 2011年 / 125卷 / 04期
基金：
日本学术振兴会;
关键词：
Cell proliferation; 5 bromo 2 ' deoxyuridine; HCT116; cells; Phytate hydrolysate; INOSITOL HEXAPHOSPHATE IP6; PHYTIC ACID IP6; WILD-TYPE P53; SMALL-INTESTINE; DNA-DAMAGE; APOPTOSIS; PROTEIN; HUMANS; INHIBITION; HYDROLYSIS;
D O I：
10.1016/j.foodchem.2010.10.037
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Phytate myo inositol hexaphosphate (IP6) has been shown to possess anti-carcinogenic qualities IP6 appears to be partially digested in the digestive tract and degraded into inositol di tri- and tetraphosphate (IP2 IP3 and IP4) The present study investigated whether IP3-rich phytate hydrolysate (IP3-RPH) a partially degraded product from phytate plays a role in the suppression of cell proliferation using an HCT116 colon carcinoma cell line IP3-RPH suppresses cell proliferation as does IP6 and the suppression activity of IP3-RPH is higher than that of IP6 Suppression modes clearly differed between IP3-RPH and IP6 Our findings suggest that partially degraded IP6 products are responsible for the suppression of colon carcinogenesis by IP6 (C) 2010 Elsevier Ltd All rights reserved
引用
收藏
页码：1219 / 1225
页数：7
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