Phytochemicals from the flowers of Prunus persica (L.) Batsch: Anti-adipogenic effect of mandelamide on 3T3-L1 preadipocytes

被引:10
|
作者
Lee, Dahae [1 ]
Kim, Ji-Young [2 ]
Qi, Yutong [2 ]
Park, Sangsu [3 ]
Lee, Hye Lim [4 ]
Yamabe, Noriko [1 ]
Kim, Hocheol [5 ]
Jang, Dae Sik [2 ]
Kang, Ki Sung [1 ]
机构
[1] Gachon Univ, Coll Korean Med, Seongnam 13120, South Korea
[2] Kyung Hee Univ, Grad Sch, Dept Life & Nanopharmaceut Sci, Seoul 02447, South Korea
[3] Kyung Hee Univ, Grad Sch, Dept Fundamental Pharmaceut Sci, Seoul 02447, South Korea
[4] Daejeon Univ, Dept Pediat, Coll Korean Med, Daejeon, South Korea
[5] Kyung Hee Univ, Dept Herbal Pharmacol, Coll Korean Med, Seoul 02447, South Korea
基金
新加坡国家研究基金会;
关键词
Prunus persica (L.) Batsch; Mandelamide; Adipocytes; Adipogenesis; DIET-INDUCED OBESITY; ADIPOCYTE DIFFERENTIATION; P38MAPK; CELLS; ACID; MICE;
D O I
10.1016/j.bmcl.2021.128326
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Flowers of Prunus persica (L.) Batsch (Rosaceae), known as peach blossoms, have been reported to exert anti-obesity effects by improving hepatic lipid metabolism in obese mice. However, little is known regarding the anti-adipogenic effects of the phenolic compounds isolated from P. persica flowers. This study investigated the inhibitory effects of compounds extracted from P. persica flowers (PPF) on adipogenesis in 3T3-L1 murine preadipocytes using adipogenic differentiation assays. Additionally, we compared the anti-adipogenic effects of the phenolic compounds isolated from PPF, such as prunasin amide (1), amygdalin amide (2), prunasin acid (3), mandelamide (4), methyl caffeate (5), ferulic acid (6), chlorogenic acid (7), benzyl alpha-L-xylpyranosyl-(1 -> 6)-beta-D- glucopyranoside (8), prunin (9), naringenin (10), nicotiflorin (11), astragalin (12), afzelin (13), and uridine (14), on adipogenesis in 3T3-L1 murine preadipocytes. PPF and compounds 4-7 and 10 significantly inhibited adipogenesis. Among them, mandelamide (4) exhibited the maximum inhibitory activity with an IC50 of 36.04 +/- 1.82 mu M. Additionally, mandelamide downregulated the expression of key adipogenic markers, such as extra cellular signal-regulated kinase, c-Jun-N-terminal kinase, P38, CCAAT/enhancer-binding protein alpha, CCAAT/enhancer-binding protein beta, peroxisome proliferator activated receptor gamma, and glucocorticoid receptor. These results indicate that mandelamide is an active ingredient of PPF possessing anti-obesity properties.
引用
收藏
页数:6
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