Physical and mechanical properties of sunflower oil and synthetic polymers based bigels for the delivery of nitroimidazole antibiotic - A therapeutic approach for controlled drug delivery

被引：61

作者：

Behera, B. ^{[1
]}

Singh, V. K. ^{[1
]}

Kulanthaivel, Senthilguru ^{[1
]}

Bhattacharya, M. K. ^{[2
]}

Paramanik, K. ^{[1
]}

Banerjee, I. ^{[1
]}

Pal, K. ^{[1
]}

机构：

[1] Natl Inst Technol, Dept Biotechnol & Med Engn, Rourkela 769008, Odisha, India

[2] Karimganj Coll, Dept Bot & Biotechnol, Karimganj 788710, Assam, India

来源：

EUROPEAN POLYMER JOURNAL | 2015年 / 64卷

关键词：

Bigels; Pseudoplastic; Viscoelastic; Diffusion; Metronidazole; Cell proliferation; POLYVINYL-ALCOHOL; RHEOLOGICAL PROPERTIES; DICLOFENAC SODIUM; SOLID DISPERSIONS; TOPICAL DELIVERY; DROPLET SIZE; XANTHAN GUM; GUAR GUM; HYDROGELS; RELEASE;

D O I：

10.1016/j.eurpolymj.2015.01.018

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Bigels of sunflower oil, span 40 and water soluble synthetic polymers (e.g. polyvinyl alcohol and polyvinyl pyrrolidone) were prepared and explored as controlled delivery vehicle for metronidazole. Fluorescence microscope was used to analyze the microstructure of the bigels. Viscometer and mechanical tester were used to study the mechanical properties of the bigels. The antimicrobial efficiency of the metronidazole loaded bigels was evaluated in vitro using Escherichia coli. The cytotoxicity studies were conducted in vitro using HaCaT cell lines. The microstructure of the bigels showed the presence of hydrogel as continuous phase and oleogels as dispersed form. The bigels were viscoelastic in nature with pseudoplastic flow behavior. A decrease in the amount of the released drug was observed with the increase in the polymer concentration in the bigels. All the bigels showed a high cell proliferation index. The drug loaded bigels showed equivalent inhibitory zones against Escherichia coli as compared to commercially available formulations. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：253 / 264

页数：12

共 61 条

[1] A comparative evaluation between utilizing SAS supercritical fluid technique and solvent evaporation method in preparation of Azithromycin solid dispersions for dissolution rate enhancement [J].