Unraveling the roles of PLIN5: linking cell biology to physiology

被引：74

作者：

Mason, Rachael R. ^{[1
]}

Watt, Matthew J. ^{[1
]}

机构：

[1] Monash Univ, Dept Physiol, Clayton, Vic 3800, Australia

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2015年 / 26卷 / 03期

基金：

英国医学研究理事会;

关键词：

lipid metabolism; triglyceride; lipid droplet; animal physiology; perilipin; mitochondrial biogenesis; HUMAN SKELETAL-MUSCLE; INTRAMUSCULAR TRIGLYCERIDE BREAKDOWN; DROPLET-ASSOCIATED PROTEINS; PERILIPIN; 5; INSULIN-RESISTANCE; LIPID DROPLETS; FATTY-ACID; TRIACYLGLYCEROL LIPASE; STIMULATED LIPOLYSIS; PAT-FAMILY;

D O I：

10.1016/j.tem.2015.01.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The discovery of perilipin (PLIN) 1 provided a major conceptual shift in the understanding of adipose tissue lipolysis and generated intense interest in lipid droplet biology research. The subsequent discovery of other PLIN proteins revealed unique tissue distribution profiles, subcellular locations, and lipid-binding properties and divergent cellular functions. PLIN5 is highly expressed in oxidative tissues such as skeletal muscle, liver, and heart and is central to lipid homeostasis in these tissues. Studies in cell systems have ascribed several metabolic roles to PLIN5 and demonstrated interactions with other proteins that are requisite for these functions. We examine recent in vivo studies and ask whether the evidence from the cell biology approaches is consistent with the physiological roles of PLIN5.

引用

页码：144 / 152

页数：9

共 80 条

[1] Adipose Overexpression of Desnutrin Promotes Fatty Acid Use and Attenuates Diet-Induced Obesity [J].

Ahmadian, Maryam ;

Duncan, Robin E. ;

Varady, Krista A. ;

Frasson, Danubia ;

Hellerstein, Marc K. ;

Birkenfeld, Andreas L. ;

Samuel, Varman T. ;

Shulman, Gerald I. ;

Wang, Yuhui ;

Kang, Chulho ;

Sul, Hei Sook .

DIABETES, 2009, 58 (04) :855-866

[2] Skeletal Muscle Triglycerides, Diacylglycerols, and Ceramides in Insulin Resistance Another Paradox in Endurance-Trained Athletes? [J].

Amati, Francesca ;

Dube, John J. ;

Alvarez-Carnero, Elvis ;

Edreira, Martin M. ;

Chomentowski, Peter ;

Coen, Paul M. ;

Switzer, Galen E. ;

Bickel, Perry E. ;

Stefanovic-Racic, Maja ;

Toledo, Frederico G. S. ;

Goodpaster, Bret H. .

DIABETES, 2011, 60 (10) :2588-2597

[3] High-Fat Diet-Mediated Lipotoxicity and Insulin Resistance Is Related to Impaired Lipase Expression in Mouse Skeletal Muscle [J].

Badin, Pierre-Marie ;

Vila, Isabelle K. ;

Louche, Katie ;

Mairal, Aline ;

Marques, Marie-Adeline ;

Bourlier, Virginie ;

Tavernier, Genevieve ;

Langin, Dominique ;

Moro, Cedric .

ENDOCRINOLOGY, 2013, 154 (04) :1444-1453

[4]

Bartholomew S.R., 2011, BIOCHIM BIOPHYS ACTA, V1821, P268

[5] PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores [J].

Bickel, Perry E. ;

Tansey, John T. ;

Welte, Michael A. .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2009, 1791 (06) :419-440

[6] Fatty acids regulate perilipin5 in muscle by activating PPARδ [J].

Bindesboll, Christian ;

Berg, Ole ;

Arntsen, Borghild ;

Nebb, Hilde I. ;

Dalen, Knut Tomas .

JOURNAL OF LIPID RESEARCH, 2013, 54 (07) :1949-1963

[7] Overexpression of PLIN5 in skeletal muscle promotes oxidative gene expression and intramyocellular lipid content without compromising insulin sensitivity [J].

Bosma, M. ;

Sparks, L. M. ;

Hooiveld, G. J. ;

Jorgensen, J. A. ;

Houten, S. M. ;

Schrauwen, P. ;

Kersten, S. ;

Hesselink, M. K. C. .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2013, 1831 (04) :844-852

[8] The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondria [J].

Bosma, Madeleen ;

Minnaard, Ronnie ;

Sparks, Lauren M. ;

Schaart, Gert ;

Losen, Mario ;

de Baets, Marc H. ;

Duimel, Hans ;

Kersten, Sander ;

Bickel, Perry E. ;

Schrauwen, Patrick ;

Hesselink, Matthijs K. C. .

HISTOCHEMISTRY AND CELL BIOLOGY, 2012, 137 (02) :205-216

[9] RETRACTED: The SNARE Protein SNAP23 and the SNARE-Interacting Protein Munc18c in Human Skeletal Muscle Are Implicated in Insulin Resistance/Type 2 Diabetes(Retracted article. See vol. 66, pg.1426, 2017) [J].

Bostrom, Pontus ;

Andersson, Linda ;

Vind, Birgitte ;

Haversen, Liliana ;

Rutberg, Mikael ;

Wickstrom, Ylva ;

Larsson, Erik ;

Jansson, Per-Anders ;

Svensson, Maria K. ;

Branemark, Richard ;

Ling, Charlotte ;

Beck-Nielsen, Henning ;

Boren, Jan ;

Hojlund, Kurt ;

Olofsson, Sven-Olof .

DIABETES, 2010, 59 (08) :1870-1878

[10] The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis [J].

Brasaemle, Dawn L. .

JOURNAL OF LIPID RESEARCH, 2007, 48 (12) :2547-2559

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