In vitro dissolution testing models of ocular implants for posterior segment drug delivery

被引:46
作者
Adrianto, Muhammad Faris [1 ,2 ]
Annuryanti, Febri [1 ,2 ]
Wilson, Clive G. [3 ]
Sheshala, Ravi [4 ]
Thakur, Raghu Raj Singh [1 ]
机构
[1] Queens Univ Belfast, Med Biol Ctr, Sch Pharm, 97 Lisburn Rd, Belfast BT9 7BL, Antrim, North Ireland
[2] Univ Airlangga, Fac Pharm, Dept Pharmaceut Chem, Surabaya 60115, East Java, Indonesia
[3] Univ Strathclyde, Strathclyde Inst Pharm & Biomed Sci, 161 Cathedral St, Glasgow G4 0RE, Lanark, Scotland
[4] Univ Teknol MARA Selangor, Fac Pharm, Dept Pharmaceut, Puncak Alam Campus, Bandar Puncak Alam 42300, Kuala Selangor, Malaysia
关键词
In vitro; Dissolution studies; Ocular implants; Posterior segment; Drug delivery; BIODEGRADABLE INTRASCLERAL IMPLANT; VIVO CORRELATION; FLUORESCEIN SODIUM; VITREOUS-HUMOR; RELEASE; EYE; DEXAMETHASONE; BARRIERS; DESIGN; SYSTEM;
D O I
10.1007/s13346-021-01043-z
中图分类号
TH7 [仪器、仪表];
学科分类号
0804 ; 080401 ; 081102 ;
摘要
The delivery of drugs to the posterior segment of the eye remains a tremendously difficult task. Prolonged treatment in conventional intravitreal therapy requires injections that are administered frequently due to the rapid clearance of the drug molecules. As an alternative, intraocular implants can offer drug release for long-term therapy. However, one of the several challenges in developing intraocular implants is selecting an appropriate in vitro dissolution testing model. In order to determine the efficacy of ocular implants in drug release, multiple in vitro test models were emerging. While these in vitro models may be used to analyse drug release profiles, the findings may not predict in vivo retinal drug exposure as this is influenced by metabolic and physiological factors. This review considers various types of in vitro test methods used to test drug release of ocular implants. Importantly, it discusses the challenges and factors that must be considered in the development and testing of the implants in an in vitro setup.
引用
收藏
页码:1355 / 1375
页数:21
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