Emerging Single-Atom Catalysts/Nanozymes for Catalytic Biomedical Applications

被引:45
作者
Wang, Zihao [1 ]
Wu, Fu-Gen [1 ,2 ,3 ]
机构
[1] Southeast Univ, Sch Biol Sci & Med Engn, State Key Lab Bioelect, 2 Sipailou Rd, Nanjing 210096, Peoples R China
[2] Guangxi Med Univ, Minist Educ, Key Lab Early Prevent & Treatment Reg High Freque, 22 Shuangyong Rd, Nanning 530022, Peoples R China
[3] Guangxi Key Lab Early Prevent & Treatment Reg Hig, 22 Shuangyong Rd, Nanning 530022, Peoples R China
基金
中国国家自然科学基金;
关键词
cancer therapy; catalytic mechanisms; redox homeostasis; ROS; single-atom catalysts; METAL-ORGANIC FRAMEWORKS; PEROXIDASE-LIKE ACTIVITY; LAYER DEPOSITION; ACTIVE-SITES; COLORIMETRIC DETECTION; SUPPORTED SINGLE; NUCLEAR DELIVERY; GOLD NANOSPIKES; MOS2; NANOSHEETS; CO OXIDATION;
D O I
10.1002/adhm.202101682
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Single-atom catalysts (SACs) are a type of atomically dispersed nanozymes with the highest atom utilization, which employ low-coordinated single atoms as the catalytically active sites. SACs not only inherit the merits of traditional nanozymes, but also hold high catalytic activity and superb catalytic selectivity, which ensure their tremendous application potential in environmental remediation, energy storage and conversion, chemical industry, nanomedicine, etc. Nevertheless, undesired aggregation effect of single atoms during preactivation and reaction processes is significantly enhanced owing to the high surface free energy of single atoms. In this case, appropriate substrates are requisite to prevent the aggregation event through the powerful interactions between the single atoms and the substrates, thereby stabilizing the high catalytic activity of the catalysts. In this review, the synthetic methods and characterization approaches of SACs are first described. Then the application cases of SACs in nanomedicine are summarized. Finally, the current challenges and future opportunities of the SACs in nanomedicine are outlined. It is hoped that this review may have implications for furthering the development of new SACs with improved biophysicochemical properties and broadened biomedical applications.
引用
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页数:26
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