A phase I study of combination of panitumumab and bevacizumab in KRAS wild-type colorectal cancer patients who were previously treated with fluoropyrimidine, oxaliplatin, irinotecan, and bevacizumab.

被引:0
作者
Takahashi, Naoki
Iwasa, Satoru
Tachikawa, Masanori
Fukahori, Masaru
Sudo, Kazuki
Sasaki, Yusuke
Shoji, Hirokazu
Honma, Yoshitaka
Okita, Natsuko
Takashima, Atsuo
Hamaguchi, Tetsuya
Boku, Narikazu
Shimada, Yasuhiro
Yamagiwa, Koki
Ebata, Yuka
Uchida, Yasuo
Honda, Kazufumi
Terasaki, Tetsuya
Yamada, Yasuhide
机构
[1] Natl Canc Ctr, Gastrointestinal Med Oncol Div, 1-1 Tsukiji 5 chome, Tokyo, Japan
[2] Tohoku Univ, Grad Sch Pharmaceut Sci, Sendai, Miyagi 980, Japan
[3] Kurume Univ Hosp, Multidisciplinary Treatment Canc Ctr, Fukuoka, Japan
[4] Natl Canc Ctr, 1-1 Tsukiji 5 chome, Tokyo, Japan
[5] Natl Canc Ctr, Chuo Ku, 1-1 Tsukiji 5 chome, Tokyo, Japan
[6] Tohoku Univ, Grad Sch Pharmaceut Sci, Sendai, Miyagi 980, Japan
[7] Natl Canc Ctr, Res Inst, Tokyo 104, Japan
关键词
D O I
10.1200/jco.2016.34.4_suppl.759
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
759
引用
收藏
页数:1
相关论文
共 50 条
[41]   A single-arm, multicenter, phase II study of panitumumab in combination with capecitabine/oxaliplatin in first line, wild-type KRAS metastatic colorectal cancer patients. [J].
Pectasides, Dimitrios G. ;
Karavasilis, Vasilios ;
Kotoula, Vassiliki ;
Samantas, Epaminontas ;
Alexopoulou, Zoi ;
Zagouri, Flora ;
Syrigos, Konstantinos N. ;
Koureas, Andreas ;
Dionysopoulos, Dimitrios ;
Lazaridis, Georgios ;
Efstratiou, Ioannis ;
Apessou, Dimitra ;
Pentheroudakis, George E. ;
Papaxoinis, George ;
Fountzilas, George .
JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (15)
[42]   CANADIAN ECONOMIC ANALYSIS OF BEVACIZUMAB, CETUXIMAB, AND PANITUMUMAB IN THE FIRST LINE TREATMENT OF KRAS WILD-TYPE METASTATIC COLORECTAL CANCER (MCRC) [J].
Lawrence, D. ;
Maschio, M. ;
Yunger, S. ;
Easaw, J. ;
Aucoin, N. ;
Weinstein, M. .
ANNALS OF ONCOLOGY, 2012, 23 :202-202
[43]   Phase II trial of S-1 plus panitumumab for wild-type KRAS unresectable colorectal cancer patients previously treated with 5-fluorouracil (5-FU), oxaliplatin and irinotecan (KSCC1103) [J].
Sakamoto, Y. ;
Yoshida, Y. ;
Ishikawa, H. ;
Ohchi, T. ;
Takeshita, H. ;
Emi, Y. ;
Komatsu, H. ;
Sawai, T. ;
Shimose, T. ;
Oki, E. ;
Saeki, H. ;
Kakeji, Y. ;
Yoshida, Y. ;
Baba, H. ;
Maehara, Y. .
ANNALS OF ONCOLOGY, 2016, 27
[44]   A phase II study of capecitabine, irinotecan, and bevacizumab in patients with previously untreated metastatic colorectal cancer [J].
Renouf, Daniel J. ;
Welch, Stephen ;
Moore, Malcolm J. ;
Krzyzanowska, Monika K. ;
Knox, Jennifer ;
Feld, Ronald ;
Liu, Geoffrey ;
MacKay, Helen ;
Petronis, Jennifer ;
Wang, Lisa ;
Chen, Eric .
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2012, 69 (05) :1339-1344
[45]   A phase II study of capecitabine, irinotecan, and bevacizumab in patients with previously untreated metastatic colorectal cancer [J].
Daniel J. Renouf ;
Stephen Welch ;
Malcolm J. Moore ;
Monika K. Krzyzanowska ;
Jennifer Knox ;
Ronald Feld ;
Geoffrey Liu ;
Helen MacKay ;
Jennifer Petronis ;
Lisa Wang ;
Eric Chen .
Cancer Chemotherapy and Pharmacology, 2012, 69 :1339-1344
[46]   Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer [J].
Amado, Rafael G. ;
Wolf, Michael ;
Peeters, Marc ;
Van Cutsem, Eric ;
Siena, Salvatore ;
Freeman, Daniel J. ;
Juan, Todd ;
Sikorski, Robert ;
Suggs, Sid ;
Radinsky, Robert ;
Patterson, Scott D. ;
Chang, David D. .
JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (10) :1626-1634
[47]   Panitumumab in Patients with KRAS Wild-Type Colorectal Cancer after Progression on Cetuximab [J].
Wadlow, Raymond ;
Hezel, Aram F. ;
Abrams, Thomas A. ;
Blaszkowsky, Lawrence S. ;
Fuchs, Charles S. ;
Kulke, Matthew H. ;
Kwak, Eunice L. ;
Meyerhardt, Jeffrey A. ;
Ryan, David P. ;
Szymonifka, Jackie ;
Wolpin, Brian M. ;
Zhu, Andrew X. ;
Clark, Jeffrey W. .
ONCOLOGIST, 2012, 17 (01) :E27-E35
[48]   phase Ib study of irinotecan, bevacizumab and biweekly trifluridine/tipiracil in patients with metastatic colorectal cancer refractory to fluoropyrimidine and oxaliplatin: Preliminary report of MODURATE study [J].
Yamazaki, K. ;
Masuishi, T. ;
Tsushima, T. ;
Muro, K. ;
Yasui, H. ;
Mori, K. ;
Taniguchi, H. .
ANNALS OF ONCOLOGY, 2020, 31 :S205-S205
[49]   Bevacizumab in combination with fluoropyrimidine-irinotecan- or fluoropyrimidine-oxaliplatin-based chemotherapy for first-line and maintenance treatment of metastatic colorectal cancer [J].
Grapsa, Dimitra ;
Syrigos, Konstantinos ;
Saif, Muhammad Wasif .
EXPERT REVIEW OF ANTICANCER THERAPY, 2015, 15 (11) :1267-1281
[50]   Phase I study of dasatinib in combination with capecitabine, oxaliplatin and bevacizumab followed by an expanded cohort in previously untreated metastatic colorectal cancer [J].
Strickler, John H. ;
McCall, Shannon ;
Nixon, Andrew B. ;
Brady, John C. ;
Pang, Herbert ;
Rushing, Christel ;
Cohn, Allen ;
Starodub, Alexander ;
Arrowood, Christy ;
Haley, Sherri ;
Meadows, Kellen L. ;
Morse, Michael A. ;
Uronis, Hope E. ;
Blobe, Gerard C. ;
Hsu, S. David ;
Zafar, S. Yousuf ;
Hurwitz, Herbert I. .
INVESTIGATIONAL NEW DRUGS, 2014, 32 (02) :330-339