ATG7 promotes the tumorigenesis of lung cancer but might be dispensable for prognosis predication: a clinicopathologic study

被引：17

作者：

Sun, Shaoxing ^{[1
,2
]}

Wang, Zhihao ^{[1
,2
]}

Tang, Fang ^{[1
,2
]}

Hu, Pengchao ^{[3
]}

Yang, Zetian ^{[4
]}

Xue, Chao ^{[4
]}

Gong, Jun ^{[1
,2
]}

Shi, Liu ^{[1
,2
]}

Xie, Conghua ^{[1
,2
]}

机构：

[1] Wuhan Univ, Zhongnan Hosp, Dept Radiat & Med Oncol, 169 Donghu Rd, Wuhan 430071, Peoples R China

[2] Wuhan Univ, Zhongnan Hosp, Hubei Key Lab Tumor Biol Behav, Wuhan, Peoples R China

[3] Wuhan Univ, Sch Basic Med Sci, Dept Pathol & Pathophysiol, Wuhan, Peoples R China

[4] Wuhan Univ, Zhongnan Hosp, Dept Thorac & Cardiovasc Surg, Wuhan, Peoples R China

来源：

ONCOTARGETS AND THERAPY | 2016年 / 9卷

关键词：

ATG7; autophagy; lung cancer; prognosis; clinicopathologic study; AUTOPHAGY MODULATION; CHLOROQUINE; TUMORS; CELLS; MACROAUTOPHAGY; HOMEOSTASIS; INHIBITOR; DISEASES; GROWTH; TARGET;

D O I：

10.2147/OTT.S107876

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Lung cancer is the most frequent cause of cancer-related death worldwide. Dysregulated autophagy is often observed in lung cancer. Autophagy-related 7 (ATG7) is an autophagy gene that is essential for the biogenesis of autophagosomes. Although ATG7-deficient mouse models have demonstrated that ATG7-dependent autophagy is required for lung cancer tumorigenesis, the relationship between ATG7 expression levels and human lung cancer is unclear. Here, we demonstrate that ATG7 was overexpressed in human lung cancer tissues compared with normal tissues. However, ATG7 expression was not associated with tumor differentiation, tumor size, or TNM stage. Moreover, the overexpression of ATG7 did not influence the overall survival of the lung cancer patients. Therefore, our results indicate that ATG7 might be dispensable for tumor growth and chemotherapy efficacy in human lung cancer.

引用

页码：4975 / 4981

页数：7

共 26 条

[1] Mammalian Autophagy: How Does It Work? [J].

Bento, Carla F. ;

Renna, Maurizio ;

Ghislat, Ghita ;

Puri, Claudia ;

Ashkenazi, Avraham ;

Vicinanza, Mariella ;

Menzies, Fiona M. ;

Rubinsztein, David C. .

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 85, 2016, 85 :685-713

[2] Cancer Treatment and Survivorship Statistics, 2014 [J].

DeSantis, Carol E. ;

Lin, Chun Chieh ;

Mariotto, Angela B. ;

Siegel, Rebecca L. ;

Stein, Kevin D. ;

Kramer, Joan L. ;

Alteri, Rick ;

Robbins, Anthony S. ;

Jemal, Ahmedin .

CA-A CANCER JOURNAL FOR CLINICIANS, 2014, 64 (04) :252-271

[3] Autophagy modulation: a target for cancer treatment development [J].

Duffy, Alison ;

Le, Jackson ;

Sausville, Edward ;

Emadi, Ashkan .

CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2015, 75 (03) :439-447

[4] Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy [J].

Eng, Christina H. ;

Wang, Zuncai ;

Tkach, Diane ;

Toral-Barza, Lourdes ;

Ugwonali, Savuth ;

Liu, Shanming ;

Fitzgerald, Stephanie L. ;

George, Elizabeth ;

Frias, Elizabeth ;

Cochran, Nadire ;

De Jesus, Rowena ;

McAllister, Gregory ;

Hoffman, Gregory R. ;

Bray, Kevin ;

Lemon, LuAnna ;

Lucas, Judy ;

Fantin, Valeria R. ;

Abraham, Robert T. ;

Murphy, Leon O. ;

Nyfeler, Beat .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (01) :182-187

[5] Non-Small Cell Lung Cancer, Version 6.2015 Featured Updates to the NCCN Guidelines [J].

Ettinger, David S. ;

Wood, Douglas E. ;

Akerley, Wallace ;

Bazhenova, Lyudmila A. ;

Borghaei, Hossein ;

Camidge, David Ross ;

Cheney, Richard T. ;

Chirieac, Lucian R. ;

D'Amico, Thomas A. ;

Demmy, Todd L. ;

Dilling, Thomas J. ;

Dobelbower, M. Chris ;

Govindan, Ramaswamy ;

Grannis, Frederic W., Jr. ;

Horn, Leora ;

Jahan, Thierry M. ;

Komaki, Ritsuko ;

Krug, Lee M. ;

Lackner, Rudy P. ;

Lanuti, Michael ;

Lilenbaum, Rogerio ;

Lin, Jules ;

Loo, Billy W., Jr. ;

Martins, Renato ;

Otterson, Gregory A. ;

Patel, Jyoti D. ;

Pisters, Katherine M. ;

Reckamp, Karen ;

Riely, Gregory J. ;

Rohren, Eric ;

Schild, Steven E. ;

Shapiro, Theresa A. ;

Swanson, Scott J. ;

Tauer, Kurt ;

Yang, Stephen C. ;

Gregory, Kristina ;

Hughes, Miranda .

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2015, 13 (05) :515-524

[6] Autophagy-Mediated Tumor Promotion [J].

Guo, Jessie Yanxiang ;

Xia, Bing ;

White, Eileen .

CELL, 2013, 155 (06) :1216-1219

[7] Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis [J].

Guo, Jessie Yanxiang ;

Karsli-Uzunbas, Gizem ;

Mathew, Robin ;

Aisner, Seena C. ;

Kamphorst, Jurre J. ;

Strohecker, Anne M. ;

Chen, Guanghua ;

Price, Sandy ;

Lu, Wenyun ;

Teng, Xin ;

Snyder, Eric ;

Santanam, Urmila ;

DiPaola, Robert S. ;

Jacks, Tyler ;

Rabinowitz, Joshua D. ;

White, Eileen .

GENES & DEVELOPMENT, 2013, 27 (13) :1447-1461

[8] Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis [J].

Guo, Jessie Yanxiang ;

Chen, Hsin-Yi ;

Mathew, Robin ;

Fan, Jing ;

Strohecker, Anne M. ;

Karsli-Uzunbas, Gizem ;

Kamphorst, Jurre J. ;

Chen, Guanghua ;

Lemons, Johanna M. S. ;

Karantza, Vassiliki ;

Coller, Hilary A. ;

DiPaola, Robert S. ;

Gelinas, Celine ;

Rabinowitz, Joshua D. ;

White, Eileen .

GENES & DEVELOPMENT, 2011, 25 (05) :460-470

[9] Autophagy and human diseases [J].

Jiang, Peidu ;

Mizushima, Noboru .

CELL RESEARCH, 2014, 24 (01) :69-79

[10] Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance [J].

Karsli-Uzunbas, Gizem ;

Guo, Jessie Yanxiang ;

Price, Sandy ;

Teng, Xin ;

Laddha, Saurabh V. ;

Khor, Sinan ;

Kalaany, Nada Y. ;

Jacks, Tyler ;

Chan, Chang S. ;

Rabinowitz, Joshua D. ;

White, Eileen .

CANCER DISCOVERY, 2014, 4 (08) :914-927

← 1 2 3 →