A case of non-small cell lung cancer presenting anti-amphiphysin antibody-positive paraneoplastic neurological syndrome

被引：6

作者：

Nakashima, Koki ^{[1
,2
]}

Fujii, Yuya ^{[1
]}

Sato, Masayuki ^{[1
,2
]}

Igarashi, Kazunari ^{[1
]}

Kobayashi, Motohiro ^{[3
]}

Ishizuka, Tamotsu ^{[2
]}

机构：

[1] Municipal Tsuruga Hosp, Dept Resp Med, 1-6-60 Mishima Cho, Tsuruga, Fukui 9148502, Japan

[2] Univ Fukui, Fac Med Sci, Dept Internal Med 3, 23-3 Matsuoka Shimoaizuki, Eiheiji, Fukui 9101193, Japan

[3] Univ Fukui, Fac Med Sci, Dept Tumor Pathol, 23-3 Matsuoka Shimoaizuki, Eiheiji, Fukui 9101193, Japan

来源：

RESPIRATORY MEDICINE CASE REPORTS | 2021年 / 34卷

基金：

日本学术振兴会;

关键词：

Paraneoplastic neurological syndrome (PNS); Amphiphysin (AMPH); Non-small cell lung cancer (NSCLC); Immune checkpoint inhibitor (ICI); Atezolizumab;

D O I：

10.1016/j.rmcr.2021.101525

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Paraneoplastic neurological syndrome (PNS) is associated with malignancies, such as small-cell lung cancer. However, patients with non-small cell lung cancer (NSCLC) rarely develop PNS. We herein report a 72-year-old man with NSCLC who developed disturbance of consciousness on the day of initiation of treatment with an immune checkpoint inhibitor. Blood test results revealed anti-amphiphysin (AMPH) antibody positively, leading to the diagnosis of PNS. The disturbance of consciousness was improved with intravenous administration of steroid and immunoglobulin. To our knowledge, this is the first report of anti-AMPH antibody-positive PNS in a patient with NSCLC.

引用

页数：3

共 12 条

[1] Paraneoplastic syndromes of the CNS [J].