Redetermination and comparative structural study of isopimpinellin: a new inhibitor against the Leishmania APRT enzyme

被引：11
作者：
Napolitano, HB
Silva, M
Ellena, J
Rocha, WC
Vieira, PC
Thiemanna, OH
Oliva, G
机构：
[1] USP, Inst Fis Sao Carlos, BR-13560970 Sao Carlos, SP, Brazil
[2] UFSCar, Dept Quim, BR-13565905 Sao Carlos, SP, Brazil
来源：
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE | 2003年 / 59卷
关键词：
D O I：
10.1107/S1600536803019925
中图分类号：
O7 [晶体学];
学科分类号：
0702 ; 070205 ; 0703 ; 080501 ;
摘要：
The title compound (alternative name 5,8-dimethoxypsoralen), C13H10O5, is a natural product extracted from Adiscanthus fusciflorus (Rutaceae). Our biochemical tests show that this compound has inhibitory activity against the enzyme adenine phosphoribosyltransferase (APRT) from Leishmania, a tropical parasite causing endemic disease in poor countries. It crystallizes in the centrosymmetric space group P2(1)/c, with one molecule in the asymmetric unit, and has at least two C-H...O intermolecular interactions, leading to the formation of centrosymmetric dimers.
引用
收藏
页码：O1506 / O1508
页数：3
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