TiO2-SiO2 Catalyzed Eco-friendly Synthesis and Antioxidant Activity of Benzopyrano[2,3-d]pyrimidine Derivatives

被引：12

作者：

Kabeer, Shaik Ahammed ^{[1
]}

Reddy, Gajjala Raghavendra ^{[1
]}

Sreelakshmi, Poola ^{[1
]}

Manidhar, Darla Mark ^{[1
]}

Reddy, Cirandur Suresh ^{[1
]}

机构：

[1] Sri Venkateswara Univ, Dept Chem, Tirupati 517502, Andhra Pradesh, India

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2017年 / 54卷 / 05期

关键词：

D O I：

10.1002/jhet.2856

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A cost-effective and eco-friendly synthesis of benzopyrano[2,3-d]pyrimidine derivatives has been developed via three component one-pot tandem approach by condensing different salicylaldehydes and secondary amines with malononitrile in the presence of TiO2-SiO2 catalyst at 80 degrees C under solvent-free conditions. Mild experimental conditions, reusability of the catalyst, and cost effectiveness are the merits of this procedure. Compounds 4g, 4h, and 4i bearing 2-OMe group on the hydroxyphenyl group linked to the central carbon present in between the two nitrogen atoms of the pyrimidine ring were found to exhibit good antioxidant activity while other compounds have moderate antioxidant activity.

引用

页码：2598 / 2604

页数：7

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