Epigenetic strategies to boost CAR T cell therapy

被引：43

作者：

Akbari, Behnia ^{[1
]}

Ghahri-Saremi, Navid ^{[1
]}

Soltantoyeh, Tahereh ^{[1
]}

Hadjati, Jamshid ^{[1
]}

Ghassemi, Saba ^{[2
]}

Mirzaei, Hamid Reza ^{[1
]}

机构：

[1] Univ Tehran Med Sci, Sch Med, Dept Med Immunol, Tehran 1417613151, Iran

[2] Univ Penn, Ctr Cellular Immunotherapies, Perelman Sch Med, Philadelphia, PA 19104 USA

来源：

MOLECULAR THERAPY | 2021年 / 29卷 / 09期

关键词：

CHIMERIC ANTIGEN RECEPTOR; HISTONE DEACETYLASE INHIBITORS; NOVO DNA METHYLATION; GENE-EXPRESSION; INTRACHROMOSOMAL INTERACTIONS; DIFFERENTIAL EXPRESSION; REGULATES EFFECTOR; VIRUS-INFECTION; UP-REGULATION; CANCER CELLS;

D O I：

10.1016/j.ymthe.2021.08.003

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Chimeric antigen receptor (CAR) T cell therapy has led to a paradigm shift in cancer immunotherapy, but still several obstacles limit CAR T cell efficacy in cancers. Advances in high throughput technologies revealed new insights into the role that epigenetic reprogramming plays in T cells. Mechanistic studies as well as comprehensive epigenome maps revealed an important role for epigenetic remodeling in T cell differentiation. These modifications shape the overall immune response through alterations in T cell phenotype and function. Here, we outline how epigenetic modifications in CAR T cells can overcome barriers limiting CAR T cell effectiveness, particularly in immunosuppressive tumor microenvironments. We also offer our perspective on how selected epigenetic modifications can boost CAR T cells to ultimately improve the efficacy of CAR T cell therapy.

引用

页码：2640 / 2659

页数：20

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