Construction and validation of a novel immune and tumor mutation burden-based prognostic model in lung adenocarcinoma

被引：9

作者：

Zhou, Bolun ^{[1
]}

Gao, Shugeng ^{[1
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Canc Hosp, Natl Clin Res Ctr Canc, Dept Thorac Surg,Natl Canc Ctr, Beijing, Peoples R China

来源：

CANCER IMMUNOLOGY IMMUNOTHERAPY | 2022年 / 71卷 / 05期

关键词：

Tumor mutation burden; Lung adenocarcinoma; Prognosis; Immunology; Immune prognostic model; CATHEPSIN-L; CANCER; METABOLISM; EXPRESSION; CELLS;

D O I：

10.1007/s00262-021-03066-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Lung adenocarcinoma (LUAD), the most common type of cancer, is hard to diagnose and has an unfavorable prognosis. Tumor mutation burden (TMB) is a useful predictor and can also determine the efficacy of immunotherapy in various cancers. The present study focused on unraveling the association between immune infiltration and TMB and developing an immune- and TMB-related prognostic model to predict LUAD patients' prognosis. The results revealed that the immune-related prognostic model (IPM) based on TMB was capable of classifying LUAD patients in all cohorts into different risk groups. The IPM was useful and had a significant correlation with LUAD patients' overall survival (OS). Based on the multivariate Cox analysis results, the IPM was proved to be an independent predictive biomarker. Furthermore, the five hub genes and the immune-related model were related to different immune infiltrating cells. The IPM was related to immune checkpoints. At last, an effective nomogram was established to predict LUAD patients' prognosis. To conclude, our IPM is effective in predicting LUAD patients' prognosis and provides novel insights into immunotherapy for LUAD.

引用

页码：1183 / 1197

页数：15

共 43 条

[11]

Isaeva O I, 2019, J Immunother Cancer, V7, P279, DOI 10.1186/s40425-019-0747-1

[12] Frequent HLA class I alterations in human prostate cancer: molecular mechanisms and clinical relevance [J].

Javier Carretero, Francisco ;

Belen del Campo, Ana ;

Francisco Flores-Martin, Jose ;

Mendez, Rosa ;

Garcia-Lopez, Cesar ;

Manuel Cozar, Jose ;

Adams, Victoria ;

Ward, Stephen ;

Cabrera, Teresa ;

Ruiz-Cabello, Francisco ;

Garrido, Federico ;

Aptsiauri, Natalia .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2016, 65 (01) :47-59

[13] PAR2 deficiency enhances myeloid cell-mediated immunosuppression and promotes colitis-associated tumorigenesis [J].

Ke, Ziliang ;

Wang, Chaohui ;

Wu, Ting ;

Wang, Weihong ;

Yang, Yong ;

Dai, Yun .

CANCER LETTERS, 2020, 469 :437-446

[14] A review of cancer immunotherapy toxicity [J].

Kennedy, Lucy Boyce ;

Salama, April K. S. .

CA-A CANCER JOURNAL FOR CLINICIANS, 2020, 70 (02) :86-104

[15] In Vivo Epigenetic CRISPR Screen Identifies Asf1a as an Immunotherapeutic Target in Kras-Mutant Lung Adenocarcinoma [J].

Li, Fei ;

Huang, Qingyuan ;

Luster, Troy A. ;

Hu, Hai ;

Zhang, Hua ;

Ng, Wai-Lung ;

Khodadadi-Jamayran, Alireza ;

Wang, Wei ;

Chen, Ting ;

Deng, Jiehui ;

Ranieri, Michela ;

Fang, Zhaoyuan ;

Pyon, Val ;

Dowling, Catriona M. ;

Bagdatlioglu, Ece ;

Almonte, Christina ;

Labbe, Kristen ;

Silver, Heather ;

Rabin, Alexandra R. ;

Jani, Kandarp ;

Tsirigos, Aristotelis ;

Papagiannakopoulos, Thales ;

Hammerman, Peter S. ;

Velcheti, Vamsidhar ;

Freeman, Gordon J. ;

Qi, Jun ;

Miller, George ;

Wong, Kwok-Kin .

CANCER DISCOVERY, 2020, 10 (02) :270-287

[16] TIMER: A Web Server for Comprehensive Analysis of Tumor-Infiltrating Immune Cells [J].

Li, Taiwen ;

Fan, Jingyu ;

Wang, Binbin ;

Traugh, Nicole ;

Chen, Qianming ;

Liu, Jun S. ;

Li, Bo ;

Liu, X. Shirley .

CANCER RESEARCH, 2017, 77 (21) :E108-E110

[17] Comparative expression analysis of PD-1, PD-L1, and CD8A in lung adenocarcinoma [J].

Ma, Ke ;

Qiao, Yulei ;

Wang, Hao ;

Wang, Shuai .

ANNALS OF TRANSLATIONAL MEDICINE, 2020, 8 (22)

[18] Current state of immunotherapy for non-small cell lung cancer [J].

Malhotra, Jyoti ;

Jabbour, Salma K. ;

Aisner, Joseph .

TRANSLATIONAL LUNG CANCER RESEARCH, 2017, 6 (02) :196-211

[19] Maftools: efficient and comprehensive analysis of somatic variants in cancer [J].

Mayakonda, Anand ;

Lin, De-Chen ;

Assenov, Yassen ;

Plass, Christoph ;

Koeffler, H. Phillip .

GENOME RESEARCH, 2018, 28 (11) :1747-1756

[20] Cyclophilin A: a key player for human disease [J].

Nigro, P. ;

Pompilio, G. ;

Capogrossi, M. C. .

CELL DEATH & DISEASE, 2013, 4 :e888-e888

← 1 2 3 4 5 →