Construction and validation of a novel immune and tumor mutation burden-based prognostic model in lung adenocarcinoma

被引：9

作者：

Zhou, Bolun ^{[1
]}

Gao, Shugeng ^{[1
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Canc Hosp, Natl Clin Res Ctr Canc, Dept Thorac Surg,Natl Canc Ctr, Beijing, Peoples R China

来源：

CANCER IMMUNOLOGY IMMUNOTHERAPY | 2022年 / 71卷 / 05期

关键词：

Tumor mutation burden; Lung adenocarcinoma; Prognosis; Immunology; Immune prognostic model; CATHEPSIN-L; CANCER; METABOLISM; EXPRESSION; CELLS;

D O I：

10.1007/s00262-021-03066-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Lung adenocarcinoma (LUAD), the most common type of cancer, is hard to diagnose and has an unfavorable prognosis. Tumor mutation burden (TMB) is a useful predictor and can also determine the efficacy of immunotherapy in various cancers. The present study focused on unraveling the association between immune infiltration and TMB and developing an immune- and TMB-related prognostic model to predict LUAD patients' prognosis. The results revealed that the immune-related prognostic model (IPM) based on TMB was capable of classifying LUAD patients in all cohorts into different risk groups. The IPM was useful and had a significant correlation with LUAD patients' overall survival (OS). Based on the multivariate Cox analysis results, the IPM was proved to be an independent predictive biomarker. Furthermore, the five hub genes and the immune-related model were related to different immune infiltrating cells. The IPM was related to immune checkpoints. At last, an effective nomogram was established to predict LUAD patients' prognosis. To conclude, our IPM is effective in predicting LUAD patients' prognosis and provides novel insights into immunotherapy for LUAD.

引用

页码：1183 / 1197

页数：15

共 43 条

[1] Increased HLA-DMB Expression in the Tumor Epithelium Is Associated with Increased CTL Infiltration and Improved Prognosis in Advanced-Stage Serous Ovarian Cancer [J].

Callahan, Michael J. ;

Nagymanyoki, Zoltan ;

Bonome, Tomas ;

Johnson, Michael E. ;

Litkouhi, Babak ;

Sullivan, Elizabeth H. ;

Hirsch, Michelle S. ;

Matulonis, Ursula A. ;

Liu, Joyce ;

Birrer, Michael J. ;

Berkowitz, Ross S. ;

Mok, Samuel C. .

CLINICAL CANCER RESEARCH, 2008, 14 (23) :7667-7673

[2] Development of tumor mutation burden as an immunotherapy biomarker: utility for the oncology clinic [J].

Chan, T. A. ;

Yarchoan, M. ;

Jaffee, E. ;

Swanton, C. ;

Quezada, S. A. ;

Stenzinger, A. ;

Peters, S. .

ANNALS OF ONCOLOGY, 2019, 30 (01) :44-56

[3]

Chen BB, 2018, METHODS MOL BIOL, V1711, P243, DOI 10.1007/978-1-4939-7493-1_12

[4] Integrative analysis of imaging and transcriptomic data of the immune landscape associated with tumor metabolism in lung adenocarcinoma: Clinical and prognostic implications [J].

Choi, Hongyoon ;

Na, Kwon Joong .

THERANOSTICS, 2018, 8 (07) :1956-1965

[5] Classification and mutation prediction from non-small cell lung cancer histopathology images using deep learning [J].

Coudray, Nicolas ;

Ocampo, Paolo Santiago ;

Sakellaropoulos, Theodore ;

Narula, Navneet ;

Snuderl, Matija ;

Fenyo, David ;

Moreira, Andre L. ;

Razavian, Narges ;

Tsirigos, Aristotelis .

NATURE MEDICINE, 2018, 24 (10) :1559-+

[6] Practical Guide to Surgical Data Sets: Surveillance, Epidemiology, and End Results (SEER) Database [J].

Doll, Kern' M. ;

Rademaker, Alfred ;

Sosa, Julie A. .

JAMA SURGERY, 2018, 153 (06) :588-589

[7] Non-Small Cell Lung Cancer, Version 1.2020 Featured Updates to the NCCN Guidelines [J].

Ettinger, David S. ;

Wood, Douglas E. ;

Aggarwal, Charu ;

Aisner, Dara L. ;

Akerley, Wallace ;

Bauman, Jessica R. ;

Bharat, Ankit ;

Bruno, Debora S. ;

Chang, Joe Y. ;

Chirieac, Lucian R. ;

D'Amico, Thomas A. ;

Dilling, Thomas J. ;

Dobelbower, Michael ;

Gettinger, Scott ;

Govindan, Ramaswamy ;

Gubens, Matthew A. ;

Hennon, Mark ;

Horn, Leora ;

Lackner, Rudy P. ;

Lanuti, Michael ;

Leal, Ticiana A. ;

Lin, Jules ;

Loo, Billy W., Jr. ;

Martins, Renato G. ;

Otterson, Gregory A. ;

Patel, Sandip P. ;

Reckamp, Karen L. ;

Riely, Gregory J. ;

Schild, Steven E. ;

Shapiro, Theresa A. ;

Stevenson, James ;

Swanson, Scott J. ;

Tauer, Kurt W. ;

Yang, Stephen C. ;

Gregory, Kristina ;

Hughes, Miranda .

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2019, 17 (12) :1464-1472

[8] Blood-based tumor mutational burden as a predictor of clinical benefit in non-small-cell lung cancer patients treated with atezolizumab [J].

Gandara, David R. ;

Paul, Sarah M. ;

Kowanetz, Marcin ;

Schleifman, Erica ;

Zou, Wei ;

Li, Yan ;

Rittmeyer, Achim ;

Fehrenbacher, Louis ;

Otto, Geoff ;

Malboeuf, Christine ;

Lieber, Daniel S. ;

Lipson, Doron ;

Silterra, Jacob ;

Amler, Lukas ;

Riehl, Todd ;

Cummings, Craig A. ;

Hegde, Priti S. ;

Sandler, Alan ;

Ballinger, Marcus ;

Fabrizio, David ;

Mok, Tony ;

Shames, David S. .

NATURE MEDICINE, 2018, 24 (09) :1441-+

[9] The Tumor Microenvironment Innately Modulates Cancer Progression [J].

Hinshaw, Dominique C. ;

Shevde, Lalita A. .

CANCER RESEARCH, 2019, 79 (18) :4557-4566

[10] Genomic Analysis of Immune Cell Infiltrates Across 11 Tumor Types [J].

Iglesia, Michael D. ;

Parker, Joel S. ;

Hoadley, Katherine A. ;

Serody, Jonathan S. ;

Perou, Charles M. ;

Vincent, Benjamin G. .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2016, 108 (11)

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