Ocular adnexal lymphoma and Helicobacter pylori gastric infection

被引：31

作者：

Decaudin, Didier ^{[1
,2
]}

Ferroni, Agnes ^{[3
,4
]}

Vincent-Salomon, Anne ^{[5
]}

Beldjord, Kheira ^{[4
,6
]}

Validire, Pierre

de Cremoux, Patricia ^{[5
]}

Validire, Patricia ^{[7
]}

Plancher, Corine ^{[8
]}

Mathiot, Claire ^{[5
]}

Macintyre, Elizabeth ^{[4
,5
]}

Asselain, Bernard ^{[8
]}

Girodet, Jacques ^{[9
]}

Mal, Frederic ^{[10
]}

Brousse, Nicole ^{[11
]}

Beretti, Jean-Luc ^{[3
]}

Dendale, Remi ^{[12
]}

Lumbroso-Le Rouic, Livia ^{[13
]}

Hermine, Olivier ^{[14
]}

Lecuit, Marc ^{[4
,15
,16
,17
]}

机构：

[1] Inst Curie, Serv Hematol Clin, Dept Clin Hematol, F-75248 Paris 05, France

[2] Inst Curie, Lab Preclin Invest, Dept Translat Res, F-75248 Paris 05, France

[3] Necker Enfants Malades Hosp, Dept Microbiol, AP HP, Paris, France

[4] Paris Descartes Univ, Paris, France

[5] Inst Curie, Mol Pharmacol Lab, Dept Tumor Biol, F-75248 Paris 05, France

[6] Necker Enfants Malades Hosp, Hematol Lab, AP HP, Paris, France

[7] Inst Mutualiste Montsouris, Dept Pathol, Paris, France

[8] Inst Curie, Dept Biostat, F-75248 Paris 05, France

[9] Inst Curie, Dept Surg, F-75248 Paris 05, France

[10] Inst Mutualiste Montsouris, Dept Gastroenterol, Paris, France

[11] Necker Enfants Malad Hosp, Dept Pathol, AP HP, Paris, France

[12] Inst Curie, Dept Radiotherapy Oncol, F-75248 Paris 05, France

[13] Inst Curie, Dept Ophthalmol, F-75248 Paris 05, France

[14] Univ Paris 05, CNRS, Dept Clin Hematol, Necker Enfants Malades Hosp,AP HP,UMR 8147, F-75270 Paris, France

[15] Necker Enfants Malades Hosp, Dept Infect Dis, AP HP, Necker Pasteur Ctr Infect Dis, Paris, France

[16] Inst Pasteur, Microbes & Host Barriers Grp, Paris, France

[17] Inserm Avenir U604, Paris, France

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 2010年 / 85卷 / 09期

关键词：

NON-HODGKINS-LYMPHOMA; B-CELL LYMPHOMA; TISSUE LYMPHOMA; MALT LYMPHOMA; SINGLE-CENTER; ASSOCIATION; CLASSIFICATION; EXPERIENCE; COMMITTEE; PSITTACI;

D O I：

10.1002/ajh.21765

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There is a causal association between Helicobacter pylori (Hp) gastric infection and the development of gastric MALT lymphoma. In contrast, the link between Hp gastric infection and the development of extragastric lymphoma has not been thoroughly investigated. We, therefore, studied the prevalence of gastric Hp infection at initial diagnosis of ophthalmologic and nonophthalmologic extragastric lymphoma patients. Three cohorts of patients were studied: a first one of 83 patients with OAL, a second one of 101 patients with extraophthalmologic extragastric lymphoma, and a third one of 156 control individuals (control) without malignant lymphoma. Gastric Hp infection was investigated by histopathological analysis and Hp-specific PCR assay on gastric biopsy tissue samples. We found gastric Hp infection in 37 OAL patients (45%), in 25 extraophthalmologic extragastric lymphoma cases (25%), and in 18 controls individuals (12%) (P < 0.0001 OAL/C and P < 0.01 OAL/extra-OAL cases). Gastritis was found in 51% and 9% of Hp-positive and Hp-negative lymphoma patients, respectively (P < 10(-4)). Gastric Hp infection only correlated with MALT/LPL lymphoma (P = 0.03). There is a significant association between gastric Hp infection and MALT/LPL OAL. This suggests a novel mechanism of indirect infection-associated lymphomagenesis whereby chronic local antigen stimulation would lead to the emergence of ectopic B-cell lymphoma. Am. J. Hematol. 85:645-649, 2010. (C) 2010 Wiley-Liss, Inc.

引用

页码：645 / 649

页数：5

共 32 条

[1]

CARBONE PP, 1971, CANCER RES, V31, P1860

[2]

CHESON BD, 1999, J CLIN ONCOL, V42, P1271

[3] Re:: Evidence for an association between Chlamydia psittaci and ocular adnexal lymphomas [J].

De Cremoux, P ;

Subtil, A ;

Ferreri, AJM ;

Vincent-Salomon, A ;

Ponzoni, M ;

Chaoui, D ;

Arnaud, P ;

Lumbroso-Le Rouic, L ;

Sacchetti, F ;

Dendale, R ;

Thioux, M ;

Escande, MC ;

Stern, MH ;

Dolcetti, R ;

Decaudin, D .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2006, 98 (05) :365-366

[4] Variable association between Chlamydophila psittaci infection and ocular adnexal lymphomas:: methodological biases or true geographical variations? [J].

Decaudin, Didier ;

Dolcetti, Riccardo ;

de Cremoux, Patricia ;

Ponzoni, Maurilio ;

Vincent-Salomon, Anne ;

Doglioni, Claudio ;

Dendale, Remi ;

Escande, Marie-Christine ;

Lumbroso-Le Rouic, Livia ;

Ferreri, Andres J. M. .

ANTI-CANCER DRUGS, 2008, 19 (08) :761-765

[5] Ocular adnexal lymphoma: a review of clinicopathologic features and treatment options [J].

Decaudin, Didier ;

de Cremoux, Patricia ;

Vincent-Salomon, Anne ;

Dendale, Remi ;

Lumbroso-Le Rouic, Livia .

BLOOD, 2006, 108 (05) :1451-1460

[6] B-cells in ocular adnexal lymphoproliferative lesions express B-cell attracting chemokine 1 (CXCL13) [J].

Falkenhagen, KM ;

Braziel, RM ;

Fraunfelder, FW ;

Smith, JR .

AMERICAN JOURNAL OF OPHTHALMOLOGY, 2005, 140 (02) :335-337

[7] Molecular pathogenesis of mucosa-associated lymphoid tissue lymphoma [J].

Farinha, P ;

Gascoyne, RD .

JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (26) :6370-6378

[8] Association between Helicobacter pylori infection and MALT-type lymphoma of the ocular adnexa:: clinical and therapeutic implications [J].

Ferreri, AJ ;

Ponzoni, M ;

Viale, E ;

Guidoboni, M ;

De Conciliis, C ;

Resti, AG ;

Politi, L ;

Lettini, AA ;

Sacchetti, F ;

Dognini, G ;

Dolcetti, R ;

Doglioni, C .

HEMATOLOGICAL ONCOLOGY, 2006, 24 (01) :33-37

[9] Evidence for an association between Chlamydia psittaci and ocular adnexal lymphomas [J].

Ferreri, AJM ;

Guidoboni, M ;

Ponzoni, M ;

De Conciliis, C ;

Dell'Oro, S ;

Fleischhauer, K ;

Caggiari, L ;

Lettini, AA ;

Dal Cin, E ;

Ieri, R ;

Freschi, M ;

Villa, E ;

Boiocchi, M ;

Dolcetti, R .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2004, 96 (08) :586-594

[10] BORRELIA-BURGDORFERI ASSOCIATED CUTANEOUS B-CELL LYMPHOMA - CLINICAL AND IMMUNOHISTOLOGIC CHARACTERIZATION OF 4 CASES [J].

GARBE, C ;

STEIN, H ;

DIENEMANN, D ;

ORFANOS, CE .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1991, 24 (04) :584-590

← 1 2 3 4 →