CEACAM1 as a multi-purpose target for cancer immunotherapy

被引：98
作者：
Dankner, Matthew [1 ]
Gray-Owen, Scott D. [2 ]
Huang, Yu-Hwa [3 ]
Blumberg, Richard S. [3 ]
Beauchemin, Nicole [1 ]
机构：
[1] McGill Univ, Goodman Canc Res Ctr, 1160 Pine Ave West,Room 623, Montreal, PQ H3A 1A3, Canada
[2] Univ Toronto, Dept Mol Genet, Toronto, ON, Canada
[3] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Gastroenterol Hepatol & Endoscopy, Boston, MA USA
来源：
ONCOIMMUNOLOGY | 2017年 / 6卷 / 07期
基金：
美国国家卫生研究院; 加拿大健康研究院;
关键词：
Cancer; cancer immunotherapy; cancer therapy; CEACAM1; NK cells; T cells; tumor marker; CELL-ADHESION MOLECULE-1; TUMOR-ASSOCIATED MACROPHAGES; INFLAMMATORY-BOWEL-DISEASE; CYTOPLASMIC DOMAIN ISOFORM; TYROSINE-PHOSPHATASE SHP-1; CARCINOEMBRYONIC ANTIGEN; BILIARY GLYCOPROTEIN; T-CELLS; NEISSERIA-GONORRHOEAE; INSULIN ENDOCYTOSIS;
D O I：
10.1080/2162402X.2017.1328336
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
CEACAM1 is an extensively studied cell surface molecule with established functions in multiple cancer types, as well as in various compartments of the immune system. Due to its multi-faceted role as a recently appreciated immune checkpoint inhibitor and tumor marker, CEACAM1 is an attractive target for cancer immunotherapy. Herein, we highlight CEACAM1's function in various immune compartments and cancer types, including in the context of metastatic disease. This review outlines CEACAM1's role as a therapeutic target for cancer treatment in light of these properties.
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页数：16
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