Serum Cartilage Oligomeric Matrix Protein in Late-Stage Osteoarthritis: Association with Clinical Features, Renal Function, and Cardiovascular Biomarkers

被引:10
|
作者
Riegger, Jana [1 ]
Rehm, Martin [2 ]
Buechele, Gisela [2 ]
Brenner, Hermann [3 ,4 ]
Guenther, Klaus-Peter [5 ]
Rothenbacher, Dietrich [2 ]
Brenner, Rolf E. [1 ]
机构
[1] Univ Ulm, Dept Orthoped, Div Biochem Joint & Connect Tissue Dis, D-89081 Ulm, Germany
[2] Ulm Univ, Inst Epidemiol & Med Biometry, Helmholtzstr 22, D-89081 Ulm, Germany
[3] German Canc Res Ctr, Div Clin Epidemiol & Aging Res, D-69120 Heidelberg, Germany
[4] Heidelberg Univ, Network Aging Res, D-69115 Heidelberg, Germany
[5] Tech Univ Dresden, Univ Ctr Orthopaed & Traumatol, Univ Med Carl Gustav Carus Dresden, D-01069 Dresden, Germany
关键词
knee osteoarthritis; hip osteoarthritis; COMP; renal function; NT-proBNP; cystatin C; biomarker; WOMAC; FFbH; KNEE OSTEOARTHRITIS; BIOCHEMICAL MARKERS; COMP; HIP; OUTCOMES; PREVALENCE; ARTHRITIS; BURDEN; INJURY; COHORT;
D O I
10.3390/jcm9010268
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
This study aimed to assess associations between serum cartilage oligomeric matrix protein (sCOMP) and phenotypic characteristics in late-stage hip and knee Osteoarthritis (OA) as well as its correlation with further serum markers of possible comorbidities in the Ulm Osteoarthritis Study. Moreover, the prognostic relevance of preoperative sCOMP concentrations for short-term functionality and pain outcomes after hip or knee joint replacement was explored. Preoperative serum samples and detailed information about the health status (i.e., WOMAC scores, Hannover Functionality Status (FFbH)) of 754 OA patients undergoing total joint replacement were included. Spearman rank-correlation coefficients and multiple linear regression models were used to evaluate the relationships between sCOMP, other serum markers, and health outcomes. There was a significant positive association between sCOMP and markers of renal (cystatin C, creatinine, and eGFR) and cardiac (e.g., NT-proBNP) impairment. Since renal failure might cause accumulation of sCOMP, additional adjustment with eGFR was performed. Preoperative sCOMP levels in knee OA but not hip OA patients were positively associated with FFbH, WOMAC function sub-scale and total WOMAC scale as well as the post-operative WOMAC stiffness sub-scale six months after surgery. Our data clearly demonstrate an association between sCOMP and renal function as well as other confounding factors, which should be considered in future biomarker studies.
引用
收藏
页数:16
相关论文
共 40 条
  • [21] Combined use of Serum miR-338-3p, Cartilage Oligomeric Matrix Protein and Chondroitin Sulfate-846 in the Early Diagnosis of Knee Osteoarthritis
    Dou, Xiaojie
    Zhang, Zhaodong
    Wang, Shuai
    Zhou, Xuemei
    CLINICAL LABORATORY, 2019, 65 (03) : 319 - 324
  • [22] Association between serum cartilage oligomeric matrix protein and coronary artery calcification in maintenance hemodialysis patients
    Ha, Lahati
    Shi, Jun-Bao
    Yu, Hai-Yi
    Yang, Kun
    Wang, Hai-Ning
    Wang, Fang-Fang
    Han, Jiang-Li
    JOURNAL OF GERIATRIC CARDIOLOGY, 2020, 17 (02) : 67 - 73
  • [23] The potential and limitations of cartilage-specific (V+C)- fibronectin and cartilage oligomeric matrix protein as osteoarthritis biomarkers in canine synovial fluid
    Steffey, MA
    Miura, N
    Todhunter, RJ
    Nykamp, SG
    Freeman, KP
    Scarpino, V
    Vernier-Singer, MA
    Erb, HN
    MacLeod, JN
    Lust, G
    Burton-Wurster, N
    OSTEOARTHRITIS AND CARTILAGE, 2004, 12 (10) : 818 - 825
  • [24] Cartilage oligomeric matrix protein in serum in systemic lupus erythematosus and knee osteoarthritis. Preliminary communication
    Wislowska, M
    Jablonska, B
    RHEUMATOLOGY INTERNATIONAL, 2005, 25 (05) : 373 - 378
  • [25] Cartilage oligomeric matrix protein in serum in systemic lupus erythematosus and knee osteoarthritis. Preliminary communication
    M. Wisłowska
    B. Jabłońska
    Rheumatology International, 2005, 25 : 373 - 378
  • [26] Serum cartilage oligomeric matrix protein reflects the presence of clinically diagnosed synovitis in patients with knee osteoarthritis
    Vilím, V
    Vytásek, R
    Olejárová, M
    Machácek, S
    Gatterová, J
    Procházka, B
    Kraus, VB
    Pavelka, K
    OSTEOARTHRITIS AND CARTILAGE, 2001, 9 (07) : 612 - 618
  • [27] Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community-based cohort of middle-aged women
    Kluzek, Stefan
    Bay-Jensen, Anne-Christine
    Judge, Andrew
    Karsdal, Morten A.
    Shorthose, Matthew
    Spector, Tim
    Hart, Deborah
    Newton, Julia L.
    Arden, Nigel K.
    BIOMARKERS, 2015, 20 (08) : 557 - 564
  • [28] Serum level of cartilage oligomeric matrix protein as a screening modality for osteoarthritis among knee joint pain patients
    Awadallah, A.
    Sabry, J.
    Shalaby, A.
    Khater, T.
    MINERVA BIOTECNOLOGICA, 2011, 23 (2-3) : 45 - 52
  • [29] Association between serum cartilage oligomeric matrix protein and coronary artery calcification in maintenance hemodialysis patients
    Lahati HA
    Jun-Bao SHI
    Hai-Yi YU
    Kun YANG
    Hai-Ning WANG
    Fang-Fang WANG
    Jiang-Li HAN
    Journal of Geriatric Cardiology, 2020, 17 (02) : 67 - 73
  • [30] Serum cartilage oligomeric matrix protein (sCOMP) is elevated in patients with knee osteoarthritis: a systematic review and meta-analysis
    Hoch, J. M.
    Mattacola, C. G.
    McKeon, J. M. Medina
    Howard, J. S.
    Lattermann, C.
    OSTEOARTHRITIS AND CARTILAGE, 2011, 19 (12) : 1396 - 1404