Dispersible chitosan particles showing bacteriostatic effect against Streptococcus mutans and their dental polishing effect

被引：3

作者：

Saita, Kanako ^{[1
]}

Nagaoka, Shoji ^{[1
,2
]}

Shirosaki, Tomohiro ^{[1
]}

Horikawa, Maki ^{[1
]}

Ihara, Hirotaka ^{[2
]}

机构：

[1] Kumamoto Ind Res Inst, Kumamoto, Japan

[2] Kumamoto Univ, Dept Appl Chem & Biochem, Kumamoto, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2020年 / 84卷 / 06期

关键词：

Chitosan; Streptococcus mutans; antibacterial activity; anti-adhesive action; dental polishing paste; BORATE CROSS-LINKING; ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; MOLECULAR-WEIGHT; NANOPARTICLES; SOLUBILITY; TOOTHPASTE; ADHESION; INSIGHTS; BIOFILM;

D O I：

10.1080/09168451.2020.1723402

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nontoxic and biodegradable chitosan is potentially useful in various applications. We prepared submicron chitosan particles with high dispersibility in aqueous solution utilizing the electrostatic interaction phase separation method described in a previous report, but using citric acid as the polyvalent anionic compound instead of sodium sulfate. The submicron chitosan particles showed significant antibacterial activity and anti-adhesive action against Streptococcus mutans, even at around neutral pH. However, chitosan granules showed no antibacterial activity under the same conditions. The addition of the chitosan particles to dental polishing paste provided stainless steel discs (the same hardness as dental enamel) with a smoother surface than polishing paste without additives. In view of their submicron size and antibacterial activity, chitosan particles could potentially be multifunctional components of oral and dental cleaning materials.

引用

页码：1265 / 1273

页数：9

共 33 条

[1] Synthesis of iron-crosslinked chitosan succinate and iron-crosslinked hydroxamated chitosan succinate and their in vitro evaluation as potential matrix materials for oral theophylline sustained-release beads [J].