Role of Nitric Oxide in Activity Control of Mechanically Gated Ionic Channels in Cardiomyocytes: NO-Donor Study

被引：7
|
作者：
Kazanski, V. E. [1 ]
Kamkin, A. G. [1 ]
Makarenko, E. Yu. [1 ]
Lysenko, N. N. [1 ]
Sutiagin, P. V. [2 ]
Bo, Tian [1 ]
Kiseleva, I. S. [1 ]
机构：
[1] NI Pirogov Russian State Med Univ, Medicobiol Fac, Dept Fundamental & Appl Physiol, Moscow, Russia
[2] NI Pirogov Russian State Med Univ, Medicobiol Fac, Dept Morphol, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2010年 / 150卷 / 01期
基金：
俄罗斯基础研究基金会;
关键词：
isolated cardiomyocytes; whole-cell ionic currents; mechanically gated channels; NO-donors; VENTRICULAR MYOCYTES; MYOCARDIAL-FUNCTION; MEMBRANE CURRENTS; STRETCH;
D O I：
10.1007/s10517-010-1052-7
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Whole-cell ionic currents through mechanically gated chnnels (MGC) were recorded in isolated cardiomyocytes under voltage clamp conditions. In unstrained cells, NO donors SNAP and DEA-NO activated MGC and induced MG-like currents. In contrast, in stretched cells with activated MGC, these NO-donors inactivated and inhibited MGC.
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页码：1 / 5
页数：5
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