The effect of ethanol on the structure of phosphatidylserine bilayers

被引：23

作者：

Wachtel, E

Borochov, N

Bach, D ^{[1
]}

Miller, IR

机构：

[1] Weizmann Inst Sci, Dept Biol Chem, IL-76100 Rehovot, Israel

[2] Ctr Technol Educ, Holon, Israel

来源：

CHEMISTRY AND PHYSICS OF LIPIDS | 1998年 / 92卷 / 02期

关键词：

DSC; phospholipids; X-ray diffraction;

D O I：

10.1016/S0009-3084(98)00018-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Thermotropic and structural effects of ethanol on phosphatidylserine (PS) membranes were investigated by differential scanning calorimetry (DSC) and X-ray diffraction. It was found that up to 15% (v/v) added ethanol, there is little change in the melting temperature of the phospholipid and no change in the interbilayer (d) spacing in the gel phase, indicating that there is no interdigitation of the hydrocarbon chains. Above the melting temperature of the phospholipid, a large decrease of the d spacing, due primarily to a decrease in the thickness of the bilayer, was found. Ethanol molecules located in the headgroup region apparently expand the area available to the headgroups with concomitant coiling of the acyl chains, resulting in marked thinning of the lipid layer. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：127 / 137

页数：11

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