SERPINB11 Expression Is Associated With Prognosis of High-grade Serous and Clear Cell Carcinoma of the Ovary

被引：2

作者：

Park, Soo Jin ^{[1
]}

Lim, Whasun ^{[2
]}

Mun, Jaehee ^{[1
]}

Paik, Haerin ^{[1
]}

Park, Sunwoo ^{[3
,4
]}

Lim, Hyunji ^{[1
]}

Kim, Junhwan ^{[1
]}

Lee, Eun Ji ^{[1
]}

Yim, Ga Won ^{[5
]}

Lee, Nara ^{[6
]}

Lee, Cheol ^{[7
]}

Kim, Jae-Weon ^{[1
]}

Song, Gwonhwa ^{[3
,4
]}

Kim, Hee Seung ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Med, Dept Obstet & Gynecol, 101 Daehak Ro, Seoul 03080, South Korea

[2] Kookmin Univ, Dept Food & Nutr, Seoul, South Korea

[3] Korea Univ, Coll Life Sci & Biotechnol, Inst Anim Mol Biotechnol, Seoul, South Korea

[4] Korea Univ, Coll Life Sci & Biotechnol, Dept Biotechnol, Seoul 02841, South Korea

[5] Dongguk Univ, Ilsan Hosp, Dept Obstet & Gynecol, Goyang, South Korea

[6] CHA Univ, CHA Gangnam Med Ctr, Dept Obstet & Gynecol, Seoul, South Korea

[7] Seoul Natl Univ, Coll Med, Dept Pathol, Seoul, South Korea

来源：

IN VIVO | 2021年 / 35卷 / 05期

关键词：

High-grade serous; clear cell; ovarian cancer; SERPINB11; prognosis; PLASMINOGEN-ACTIVATOR INHIBITOR-2; POOR-PROGNOSIS; MASPIN EXPRESSION; CANCER; ENDOMETRIOSIS; PATHOGENESIS; MECHANISMS; SURVIVAL; MARKER; GENE;

D O I：

10.21873/invivo.12547

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Background/Aim: To evaluate the role of serine protease inhibitor B11 (SERPINB11) expression as a prognostic biomarker in high-grade serous carcinoma (HGSC) and clear cell carcinoma of the ovary (CCC). Materials and Methods: We obtained tumor tissues from patients with HGSC (n=145) and CCC (n=59). We evaluated immunohistochemically the expression of SERPINB11 and investigated whether SERPINB11 expression affects platinum-resistance and the prognosis of HGSC and CCC. Results: High expression of SERPINB11 was more common in CCC than in HGSC (57.6% vs. 28.3%; p<0.01), and SEPRINB11 expression did not correlate with platinum-resistance of HGSC and CCC. High expression of SERPINB11 was associated with worse progression-free survival and overall survival with marginal significance in HGSC; no relation between SERPINB11 expression and the prognosis of CCC was found. Conclusion: SERPINB11 expression maybe a prognostic biomarker for HGSC.

引用

页码：2647 / 2653

页数：7

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