Auditory discrimination after left-hemisphere stroke -: A mismatch negativity follow-up study

被引:56
作者
Ilvonen, TM
Kujala, T
Kiesiläinen, A
Salonen, O
Kozou, H
Pekkonen, E
Roine, RO
Kaste, M
Näätänen, R
机构
[1] Univ Helsinki, Helsinki Collegium Adv Studies, FIN-00014 Helsinki, Finland
[2] Univ Helsinki, Dept Psychol, Cognit Brain Res Unit, FIN-00014 Helsinki, Finland
[3] Univ Helsinki, Helsinki Brain Res Ctr, FIN-00014 Helsinki, Finland
[4] Univ Helsinki, Cent Hosp, Dept Neurol, Helsinki, Finland
[5] Univ Helsinki, Cent Hosp, Dept Radiol, Helsinki, Finland
关键词
aphasia; hearing disorders; laterality; mismatch negativity; speech; stroke outcome;
D O I
10.1161/01.STR.0000078836.26328.3B
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background and Purpose - We sought to determine the recovery of cortical auditory discrimination in aphasic, left-hemisphere-stroke patients by using an electrophysiological response called mismatch negativity (MMN) and speech-comprehension tests. Methods - MMN in 8 left-hemisphere stroke patients was recorded in response to duration and frequency changes in a repetitive, harmonically rich tone 4 and 10 days and again 3 and 6 months after their first unilateral stroke. Eight age-matched, healthy persons served as control subjects. Results - At 4 days after stroke onset, patients' sound discrimination was impaired in their left hemisphere, as suggested by attenuated MMNs, especially to right-ear stimuli. At 3 months after stroke, however, MMN to the right-ear duration change had significantly increased and was of normal size. A significant change for the frequency MMN was found for left-ear stimuli between 3 and 6 months after stroke. During the follow-up period, progressive improvement in speech-comprehension tests was also observed. Furthermore, there was a significant correlation between the change in the duration MMN amplitude and the Boston Diagnostic Aphasia Examination speech-comprehension test from 10 days to 3 months after stroke. Conclusions - These results suggest that the MMN can be used as an index of the recovery of auditory discrimination.
引用
收藏
页码:1746 / 1751
页数:6
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