共 38 条
High Levels of Expression of Human Stromal Cell-Derived Factor-1 Are Associated with Worse Prognosis in Patients with Stage II Pancreatic Ductal Adenocarcinoma
被引:59
作者:
Liang, John J.
[2
]
Zhu, Shaobo
[3
]
Bruggeman, Richard
[2
]
Zaino, Richard J.
[2
]
Evans, Douglas B.
[4
]
Fleming, Jason B.
[5
]
Gomez, Henry F.
[5
]
Zander, Dani S.
[2
]
Wang, Huamin
[1
]
机构:
[1] Univ Texas MD Anderson Canc Ctr, Dept Pathol, Unit 085, Houston, TX 77030 USA
[2] Penn State Milton S Hershey Med Ctr, Dept Pathol, Hershey, PA 17033 USA
[3] Geisinger Med Ctr, Dept Pathol, Danville, PA 17822 USA
[4] Med Coll Wisconsin, Dept Surg, Milwaukee, WI 53226 USA
[5] Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA
关键词:
BREAST-CANCER METASTASIS;
LYMPH-NODE METASTASIS;
CHEMOKINE RECEPTOR;
LUNG-CANCER;
INTRAEPITHELIAL NEOPLASIA;
TUMOR-GROWTH;
CXCR4;
SDF-1;
PROGRESSION;
MIGRATION;
D O I:
10.1158/1055-9965.EPI-10-0405
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
Background: Stromal cell-derived factor-1 (SDF-1) and its receptor, CXCR4, have been shown to mediate invasiveness and metastatic behavior in a number of cancers, including ovarian, prostate, bladder, breast, and pancreatic cancers. The expression and significance of SDF-1 in pancreatic ductal adenocarcinoma (PDA) have not been systematically studied. Methods: We examined the expression of SDF-1 by immunohistochemistry using a mouse anti-human SDF-1/CXCL12 antibody (dilution 1: 300) and a tissue microarray consisting of 72 stage II PDAs from pancreaticoduodenectomy specimens. The staining results were categorized as SDF-1-high (SDF-1-H; cytoplasmic staining of >= 10% of tumor cells) or SDF-1-low (SDF-1-L; no staining or staining of <10% of tumor cells). The results of SDF-1 expression were correlated with clinicopathologic parameters and survival. Statistical analyses were done using SPSS software. Result: Of the 72 stage II PDAs, 25 (35%) showed high levels of SDF-1 expression. The median overall and recurrence-free survival for patients with SDF-1-H PDAs were 26.1 and 11.1 months, respectively, compared with 44.3 and 22.3 months for patients with SDF-1-L tumors (log-rank test, P = 0.047 and P = 0.021). In multivariate analysis, high SDF-1 expression correlated with poor overall and disease-free survival (P = 0.02 and P = 0.02) independent of tumor size, differentiation, and lymph node status. Conclusion: High levels of SDF-1 expression were associated with poor overall and disease-free survival in patients with stage II PDA. SDF-1 may serve as a useful prognostic marker for stage II PDA. Impact: Our results suggest that SDF-1-CXCR4 or SDF-1-CXCR7 pathways may represent a potential target for therapeutic intervention as well as prediction of prognosis in PDA. Cancer Epidemiol Biomarkers Prev; 19(10); 2598-604. (C) 2010 AACR.
引用
收藏
页码:2598 / 2604
页数:7
相关论文