The influence of circular RNAs on autophagy and disease progression

被引：117

作者：

Wang, Yian ^{[1
,2
,3
,4
]}

Mo, Yongzhen ^{[1
,2
,3
,4
]}

Peng, Miao ^{[1
,2
,3
,4
]}

Zhang, Shanshan ^{[5
]}

Gong, Zhaojian ^{[6
]}

Yan, Qijia ^{[5
]}

Tang, Yanyan ^{[1
,2
,3
]}

He, Yi ^{[1
,2
,3
]}

Liao, Qianjin ^{[1
,2
,3
]}

Li, Xiayu ^{[7
]}

Wu, Xu ^{[4
]}

Xiang, Bo ^{[4
]}

Zhou, Ming ^{[4
]}

Li, Yong ^{[8
]}

Li, Guiyuan ^{[1
,2
,3
,4
]}

Li, Xiaoling ^{[1
,2
,3
,4
]}

Zeng, Zhaoyang ^{[1
,2
,3
,4
]}

Guo, Can ^{[1
,2
,3
,4
]}

Xiong, Wei ^{[1
,2
,3
,4
]}

机构：

[1] Cent South Univ, NHC Key Lab Carcinogenesis, 283 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China

[2] Cent South Univ, Hunan Canc Hosp, Hunan Key Lab Canc Metab, 283 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China

[3] Cent South Univ, Xiangya Sch Med, Affiliated Canc Hosp, 283 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China

[4] Cent South Univ, Canc Res Inst, Key Lab Carcinogenesis & Canc Invas, Chinese Minist Educ, Changsha, Hunan, Peoples R China

[5] Cent South Univ, Xiangya Hosp, Dept Stomatol, Changsha, Hunan, Peoples R China

[6] Cent South Univ, Xiangya Hosp 2, Dept Oral & Maxillofacial Surg, Changsha, Hunan, Peoples R China

[7] Cent South Univ, Xiangya Hosp 3, Dis Genome Res Ctr, Hunan Key Lab Nonresolving Inflammat & Canc, Changsha, Hunan, Peoples R China

[8] Baylor Coll Med, Dan L Duncan Comprehens Canc Ctr, Dept Med, Houston, TX 77030 USA

来源：

AUTOPHAGY | 2021年

基金：

中国国家自然科学基金;

关键词：

Autophagy; cancer; cardiovascular disease; circRNAs; neurological disease; ENDOPLASMIC-RETICULUM STRESS; BREAST-CANCER CELLS; PACLITAXEL RESISTANCE; MODULATES AUTOPHAGY; CONJUGATION SYSTEM; ER STRESS; INJURY; PHOSPHORYLATION; PROLIFERATION; CONTRIBUTES;

D O I：

10.1080/15548627.2021.1917131

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Circular RNAs (circRNAs) are non-coding RNAs that have attracted considerable attention in recent years. Owing to their distinct circular structure, circRNAs are stable in cells. Autophagy is a catabolic process that helps in the degradation and recycling of harmful or inessential biological macromolecules in cells and enables cells to adapt to stress and changes in the internal and external environments. Evidence has shown that circRNAs influence the course of a disease by regulating autophagy, which indicates that autophagy is involved in the onset and development of various diseases and can affect drug resistance (for example, it affects cisplatin resistance in tumors). In this review, we summarized the role of circRNAs in autophagy and their influence on disease onset and progression as well as drug resistance. The review will expand our understanding of tumors as well as cardiovascular and neurological diseases and also suggest novel therapeutic strategies.Abbreviations: ACR: autophagy-related circRNA; ADSCs: adipogenic mesenchymal stem cells; AMPK: AMP-activated protein kinase; ATG: autophagy related; BCL2: BCL2 apoptosis regulator; BECN1: beclin 1; ceRNA: competing endogenous RNA; circRNA: circular RNA; CMA: chaperone-mediated autophagy; EPCs: endothelial progenitor cells; LE/MVBs: late endosomes/multivesicular bodies; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MTOR: mechanistic target of rapamycin kinase; NSCLC: non-small cell lung cancer; PDLSCs: periodontal ligament stem cells; PE: phosphatidylethanolamine; PtdIns: phosphatidylinositol; PtdIns3K: phosphatidylinositol 3-kinase; PtdIns3P: phosphatidylinositol-3-phosphate 1,2-dipalmitoyl; PTEN: phosphatase and tensin homolog; RBPs: RNA-binding proteins; SiO2: silicon dioxide; TFEB: transcription factor EB; ULK: unc-51 like autophagy activating kinase 1

引用

页码：240 / 253

页数：14

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