Blind Evaluation of Hybrid Protein Structure Analysis Methods based on Cross-Linking

被引:17
作者
Belsom, Adam [1 ]
Schneider, Michael [2 ]
Brock, Oliver [2 ]
Rappsilber, Juri [1 ,3 ]
机构
[1] Univ Edinburgh, Wellcome Trust Ctr Cell Biol, Edinburgh EH9 3BF, Midlothian, Scotland
[2] Tech Univ Berlin, Dept Elect Engn & Comp Sci, Robot & Biol Lab, D-10587 Berlin, Germany
[3] Tech Univ Berlin, Inst Biotechnol, Chair Bloanalyt, D-13355 Berlin, Germany
基金
英国惠康基金;
关键词
MASS-SPECTROMETRY; BIOLOGY;
D O I
10.1016/j.tibs.2016.05.005
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Hybrid methods combine experimental data and computational modeling to analyze protein structures that are elusive to structure determination. To spur the development of hybrid methods, we propose to test them in the context of the GASP experiment and would like to invite experimental groups to participate in this initiative.
引用
收藏
页码:564 / 567
页数:4
相关论文
共 15 条
[1]  
[Anonymous], 2013, Database
[2]   Serum Albumin Domain Structures in Human Blood Serum by Mass Spectrometry and Computational Biology [J].
Belsom, Adam ;
Schneider, Michael ;
Fischer, Lutz ;
Brock, Oliver ;
Rappsilber, Juri .
MOLECULAR & CELLULAR PROTEOMICS, 2016, 15 (03) :1105-1116
[3]   The Protein Data Bank [J].
Berman, HM ;
Westbrook, J ;
Feng, Z ;
Gilliland, G ;
Bhat, TN ;
Weissig, H ;
Shindyalov, IN ;
Bourne, PE .
NUCLEIC ACIDS RESEARCH, 2000, 28 (01) :235-242
[4]   CAPRI: A Critical Assessment of PRedicted Interactions [J].
Janin, J ;
Henrick, K ;
Moult, J ;
Ten Eyck, L ;
Sternberg, MJE ;
Vajda, S ;
Vasker, I ;
Wodak, SJ .
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2003, 52 (01) :2-9
[5]   Protein folding and de novo protein design for biotechnological applications [J].
Khoury, George A. ;
Smadbeck, James ;
Kieslich, Chris A. ;
Floudas, Christodoulos A. .
TRENDS IN BIOTECHNOLOGY, 2014, 32 (02) :99-109
[6]  
Kryshtafovych A., 2016, CASP11 STAT PREDICTI
[7]  
Kryshtafovych A., 2015, METHODS MODEL ACCURA
[8]   Crosslinking and Mass Spectrometry: An Integrated Technology to Understand the Structure and Function of Molecular Machines [J].
Leitner, Alexander ;
Faini, Marco ;
Stengel, Florian ;
Aebersold, Ruedi .
TRENDS IN BIOCHEMICAL SCIENCES, 2016, 41 (01) :20-32
[9]  
Monastyrskyy B., 2015, NEW ENCOURAGING DEV
[10]  
Salt A., 2015, STRUCTURE, V23, P1156