Gene essentiality, gene duplicability and protein connectivity in human and mouse

被引：90

作者：

Liang, Han ^{[1
]}

Li, Wen-Hsiung ^{[1
]}

机构：

[1] Univ Chicago, Dept Ecol & Evolut, Chicago, IL 60637 USA

来源：

TRENDS IN GENETICS | 2007年 / 23卷 / 08期

关键词：

D O I：

10.1016/j.tig.2007.04.005

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

It has previously been found that, in yeast, gene essentiality is positively correlated with protein connectivity (number of interaction partners) but negatively correlated with the existence of gene duplicates and that highly connected proteins tend to have a low gene duplicability. Using data from human and mouse, we show here that, in mammals, the first of these relationships holds true, but unlike the second relationship in yeast, highly connected mammalian proteins tend to have a high gene duplicability, and there is no correlation between gene essentiality and gene duplication in mammals.

引用

页码：375 / 378

页数：4

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