Relationship between lipid metabolism state, lipid peroxidation and antioxidant defense system in girls with constitutional obesity

The study of the molecular mechanisms involved in adolescent obesity formation is important due to the severe and prolonged complications in adulthood. Here, we analyzed the lipid metabolism and peroxidation systems and the relationships between them in girls with constitutional obesity. Thirty-nine adolescent girls 14-16 age with constitutional obesity and twenty-six girls with a normal body mass index (control group) of the same age were examined. Spectrophotometric and fluorometric research methods were used. Constitutional obesity in adolescent girls is accompanied by the development of dyslipidemia (increased concentrations of total cholesterol, triacylglycerols, and very-low-density lipoproteins), as well as by reduced antioxidant defense components (total antioxidant activity, retinol, and the oxidized form of glutathione). In addition, adolescent girls with constitutional obesity had an increased number of correlations in the lipid peroxidation-antioxidant defense system and intersystem correlations, which indicates the insufficient activity of the antioxidant defense system. These results increase our understanding of the pathogenic mechanisms involved in adolescent.