Ergostane-Type Sterols from King Trumpet Mushroom (Pleurotus eryngii) and Their Inhibitory Effects on Aromatase

被引：14

作者：

Kikuchi, Takashi ^{[1
]}

Motoyashiki, Naoki ^{[1
]}

Yamada, Takeshi ^{[1
]}

Shibatani, Kanae ^{[2
]}

Ninomiya, Kiyofumi ^{[2
]}

Morikawa, Toshio ^{[2
]}

Tanaka, Reiko ^{[1
]}

机构：

[1] Osaka Univ Pharmaceut Sci, Fac Pharmaceut Sci, 4-20-1 Nasahara, Takatsuki, Osaka 5691094, Japan

[2] Kindai Univ, Pharmaceut Res & Technol Inst, 3-4-1 Kowakae, Osaka 5778502, Japan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2017年 / 18卷 / 11期

关键词：

Pleurotus eryngii; sterol; ergostane; aromatase inhibitor; 2 EDIBLE MUSHROOMS; MAMMEA-SIAMENSIS; FRUITING BODIES; POLYSACCHARIDE; CONSTITUENTS; EDODES; CANCER;

D O I：

10.3390/ijms18112479

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two new ergostane-type sterols; (22E)-5,6-epoxyergosta-8,14,22-triene-3,7-diol (1) and 5,6-epoxyergost-8(14)-ene-3,7-diol (2) were isolated from the fruiting bodies of king trumpet mushroom (Pleurotus eryngii), along with eight known compounds (3-10). All isolated compounds were evaluated for their inhibitory effects on aromatase. Among them, 4 and 6 exhibited comparable aromatase inhibitory activities to aminoglutethimide.

引用

页数：10

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