Synthesis of Aryl Dithiocarbamates from Tetramethylthiuram Monosulfide (TMTM) and Aryl Boronic Acids: Copper-Catalyzed Construction of C(sp2)-S Bonds

被引：5

作者：

Xia, Xu-Ling ^{[1
]}

Zhu, Qi-Long ^{[1
]}

Chen, Jin-Quan ^{[1
]}

Shi, Zhen ^{[2
]}

Dong, Zhi-Bing ^{[1
,2
,3
,4
]}

机构：

[1] Sch Chem & Environm Engn, Wuhan Inst Technol, Wuhan 430205, Peoples R China

[2] Hubei Minzu Univ, Hubei Key Lab Biol Resources Protect & Utilizat, Beijing 445000, Peoples R China

[3] Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China

[4] Minist Educ, Wuhan Inst Technol, Key Lab Green Chem Proc, Wuhan 430205, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2022年 / 54卷 / 02期

关键词：

dithiocarbamates; tetramethylthiuram monosulfide; boronic acids; organosulfur; copper; CROSS-COUPLING REACTIONS; TETRAALKYLTHIURAM DISULFIDES; S-ARYLATION; EFFICIENT SYNTHESIS; ONE-POT; DERIVATIVES; SULFIDES; IODIDES; THIOLATION; THIOAMIDES;

D O I：

10.1055/a-1645-6040

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly efficient method for the synthesis of S-aryl dithiocarbamates is reported. By using tetramethylthiuram monosulfide (TMTM) and aryl boronic acids as starting materials, C(sp(2))-S bond-forming reactions proceed smoothly to give the desired aryl dithiocarbamates in good to excellent yields. The methodology features a simple procedure, broad functional group tolerance and excellent yields, whilst showing potential synthetic value for the preparation of a diverse range of biologically and pharmaceutically active compounds.

引用

页码：475 / 482

页数：8

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