The Impact of Alcohol-Induced Dysbiosis on Diseases and Disorders of the Central Nervous System

被引：11
作者：
Liu, Xiangqian [1 ,2 ]
Vigorito, Michael [1 ,3 ]
Huang, Wenfei [1 ,4 ]
Khan, Mohammed A. S. [5 ,6 ]
Chang, Sulie L. [1 ,4 ]
机构：
[1] Inst Neuroimmune Pharmacol, Seton Hall Univ, S Orange, NJ 07079 USA
[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Basic Med, Dept Histol & Embryol, Wuhan 430030, Peoples R China
[3] Seton Hall Univ, Dept Psychol, S Orange, NJ 07079 USA
[4] Seton Hall Univ, Dept Biol Sci, S Orange, NJ 07079 USA
[5] Harvard Med Sch, Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, Boston, MA 02114 USA
[6] Shriners Hosp Children, Boston, MA 02114 USA
来源：
JOURNAL OF NEUROIMMUNE PHARMACOLOGY | 2022年 / 17卷 / 1-2期
基金：
美国国家卫生研究院;
关键词：
Microbiota; Neuroinflammation; Alzheimer's disease; Parkinson's disease; Addiction; QIAGEN Ingenuity Pathway Analysis; ACUTE BINGE DRINKING; GUT-BRAIN AXIS; PARKINSONS-DISEASE; SPECTRUM DISORDERS; INTESTINAL BARRIER; ORAL MICROBIOTA; GENE-EXPRESSION; IMMUNE-SYSTEM; HUMAN HEALTH; HPA AXIS;
D O I：
10.1007/s11481-021-10033-4
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The human digestive tract contains a diverse and abundant microbiota that is important for health. Excessive alcohol use can disrupt the balance of these microbes (known as dysbiosis), leading to elevated blood endotoxin levels and systemic inflammation. Using QIAGEN Ingenuity Pathway Analysis (IPA) bioinformatics tool, we have confirmed that peripheral endotoxin (lipopolysaccharide) mediates various cytokines to enhance the neuroinflammation signaling pathway. The literature has identified alcohol-mediated neuroinflammation as a possible risk factor for the onset and progression of neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD), and psychiatric disorders such as addiction to alcohol and other drugs. In this review, we discuss alcohol-use-induced dysbiosis in the gut and other body parts as a causal factor in the progression of Central Nervous System (CNS) diseases including neurodegenerative disease and possibly alcohol use disorder.
引用
收藏
页码：131 / 151
页数：21
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