Prevalence and severity of coronary artery disease in diabetic patients with aortic valve calcification

被引:10
作者
Chen, Zhang-wei [1 ]
Qian, Ju-ying [1 ]
Ma, Jian-ying [1 ]
Ge, Lei [1 ]
Liu, Xue-bo [1 ]
Shu, Xian-hong [1 ]
Ge, Junbo [1 ]
机构
[1] Fudan Univ, Zhongshan Hosp, Shanghai Inst Cardiovasc Dis, Dept Cardiol, Shanghai 200032, Peoples R China
关键词
Aortic valve calcification; coronary artery disease; diabetes; Gensini score; VASCULAR CALCIFICATION; ATHEROSCLEROSIS; ASSOCIATION; POPULATION; MELLITUS; STENOSIS; PATHOPHYSIOLOGY; PATHOGENESIS; PREDICTORS; MECHANISMS;
D O I
10.2143/AC.66.1.2064962
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective Aortic valve calcification (AVC) is common in the elderly and associated with increased cardiovascular mortality, while diabetes is one of the confirmed risk factors for coronary artery disease (CAD). In this study, we aimed to evaluate the prevalence and severity of CAD in type-2 diabetic patients with AVC. Methods From June to December in 2007, a total of 325 consecutive patients with chest pain or chest distress were admitted for coronary angiography. The severity of CAD was evaluated by the Gensini score and the number of stenosed vessels. All patients underwent transthoracic echocardiography for detecting AVC. Results Compared with the patients without diabetes (n = 221), the type-2 diabetic patients (n = 104) had a similar prevalence of CAD (66.5% vs. 72.1%, P = 0.312). Further classified by the presence of AVC, patients with AVC had a higher prevalence of CAD, average Gensini score and the number of stenosed vessels, both in the group with and without diabetes. It was also demonstrated that the odds ratio (OR) of AVC for CAD in the diabetic patients was higher than in the non-diabetic ones (3.405 vs 2.515) after chi-square analysis (single-variable). However, at multivariable logistic regression analysis for CAD, the OR of AVC was 3.757 (P = 0.03) in diabetic group, while it did not achieve statistical significance in the non-diabetic group (OR = 2.130, P = 0.074). Conclusions Type-2 diabetic patients with AVC had a higher prevalence of and more severe CAD.
引用
收藏
页码:15 / 20
页数:6
相关论文
共 26 条
[1]   Vascular calcification - Mechanisms and clinical ramifications [J].
Abedin, M ;
Tintut, Y ;
Demer, LL .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2004, 24 (07) :1161-1170
[2]   Nonobstructive aortic valve calcium as a window to atherosclerosis of the aorta [J].
Adler, Y ;
Vaturi, M ;
Wiser, I ;
Shapira, Y ;
Herz, I ;
Weisenberg, D ;
Sela, N ;
Battler, A ;
Sagie, A .
AMERICAN JOURNAL OF CARDIOLOGY, 2000, 86 (01) :68-71
[3]   Nonobstructive aortic valve calcification: a window to significant coronary artery disease [J].
Adler, Y ;
Vaturi, M ;
Herz, I ;
Iakobishvili, Z ;
Toaf, J ;
Fink, N ;
Battler, A ;
Sagie, A .
ATHEROSCLEROSIS, 2002, 161 (01) :193-197
[4]   Aortic valve sclerosis and aortic atherosclerosis: Different manifestations of the same disease? Insights from a population-based study [J].
Agmon, Y ;
Khandheria, BK ;
Meissner, I ;
Sicks, JD ;
O'Fallon, WM ;
Wiebers, DO ;
Whisnant, JP ;
Seward, JB ;
Tajik, AJ .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2001, 38 (03) :827-834
[5]   Aortic valve calcification: basic science to clinical practice [J].
Akat, K. ;
Borggrefe, M. ;
Kaden, J. J. .
HEART, 2009, 95 (08) :616-623
[6]   Mechanisms determining course and outcome of diabetic patients who have had acute myocardial infarction [J].
Aronson, D ;
Rayfield, EJ ;
Chesebro, JH .
ANNALS OF INTERNAL MEDICINE, 1997, 126 (04) :296-306
[7]   Diabetes and atherosclerosis - Epidemiology, pathophysiology, and management [J].
Beckman, JA ;
Creager, MA ;
Libby, P .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2002, 287 (19) :2570-2581
[8]   Diabetes mellitus and coronary artery disease [J].
Bell, DSH .
CORONARY ARTERY DISEASE, 1996, 7 (10) :715-722
[9]   Angiogenic activation of valvular endothelial cells in aortic valve stenosis [J].
Chalajour, F ;
Treede, H ;
Ebrahimnejad, A ;
Lauke, H ;
Reichenspurner, H ;
Ergun, S .
EXPERIMENTAL CELL RESEARCH, 2004, 298 (02) :455-464
[10]   Cardiorespiratory fitness and body mass index as predictors of cardiovascular disease mortality among men with diabetes [J].
Church, TS ;
LaMonte, MJ ;
Barlow, CE ;
Blair, SN .
ARCHIVES OF INTERNAL MEDICINE, 2005, 165 (18) :2114-2120