Does Aspirin Have a Role in Venous Thromboembolism Prophylaxis in Total Knee Arthroplasty Patients?

被引：109

作者：

Bozic, Kevin J. ^{[1
,2
]}

Vail, Thomas P. ^{[5
]}

Pekow, Penelope S. ^{[3
,4
]}

Maselli, Judith H. ^{[5
]}

Lindenauer, Peter K. ^{[3
,4
]}

Auerbach, Andrew D. ^{[6
]}

机构：

[1] Univ Calif San Francisco, Dept Orthoped Surg, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Philip R Lee Inst Hlth Policy Studies, San Francisco, CA 94143 USA

[3] Univ Massachusetts, Ctr Qual Care Res, Amherst, MA 01003 USA

[4] Univ Massachusetts, Sch Publ Hlth & Hlth Sci, Amherst, MA 01003 USA

[5] Univ Calif San Francisco, Dept Orthopaed Surg, San Francisco, CA 94143 USA

[6] Univ Calif San Francisco, Div Hosp Med, San Francisco, CA 94143 USA

来源：

JOURNAL OF ARTHROPLASTY | 2010年 / 25卷 / 07期

关键词：

outcomes; total knee arthroplasty; venous thromboembolism prophylaxis (VTEP); aspirin; clinical practice guidelines; ATRIAL-FIBRILLATION; DOSE ASPIRIN; REPLACEMENT; PREVENTION; COMPLICATIONS; WARFARIN; OUTCOMES; THERAPY; METAANALYSIS; COMPRESSION;

D O I：

10.1016/j.arth.2009.06.021

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

The objectives of this study were to compare the risk of venous thromboembolism (VTE), bleeding, surgical site infection, and mortality in patients receiving aspirin or guideline-approved VTE prophylactic therapies (warfarin, low-molecular-weight heparins, synthetic pentasaccharides) in total knee arthroplasty (TKA). We analyzed clinical and administrative data from 93 840 patients who underwent primary TKA at 307 US hospitals over a 24-month period. Fifty-one thousand nine hundred twenty-three (55%) patients received warfarin, 37 198 (40%) received injectable agents, and 4719 (5%) received aspirin. After adjustment for patient and hospital factors, patients who received aspirin VTE prophylaxis (VTEP) had lower odds for thromboembolism compared to warfarin patients but with similar odds compared with injectable VTEP; there were no differences in risk of bleeding, infection, or mortality after adjustment. Our results suggest that aspirin, when used in conjunction with other clinical care protocols, may be effective VTEP for certain TKA patients.

引用

页码：1053 / 1060

页数：8

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