Cisplatin Application in Pregnancy: First in vivo Analysis of 7 Patients

被引：41
作者：
Marnitz, Simone [3 ,4 ]
Koehler, Christhardt [1 ]
Oppelt, Peter [5 ]
Schmittel, Alexander [2 ]
Favero, Giovanni [1 ]
Hasenbein, Kati [1 ]
Schneider, Achim [1 ]
Markman, Maurie [6 ]
机构：
[1] Charite Univ Med Berlin, Dept Gynecol, DE-10117 Berlin, Germany
[2] Charite Univ Med Berlin, Dept Hematooncol, DE-10117 Berlin, Germany
[3] Charite Univ Med Berlin, Dept Radiooncol, DE-10117 Berlin, Germany
[4] Charite Univ Med Berlin, CVK, DE-10117 Berlin, Germany
[5] Gen Hosp Linz, Dept Gynecol, Linz, Austria
[6] Univ Texas MD Anderson Canc Ctr, Dept Gynecol Oncol, Houston, TX 77030 USA
来源：
ONCOLOGY | 2010年 / 79卷 / 1-2期
关键词：
Cervical cancer in pregnancy; Neoadjuvant chemotherapy; Transplacental passage; Laparoscopic staging; Cisplatin concentration; INVASIVE CERVICAL-CANCER; ADVANCED-STAGE; NEOADJUVANT CHEMOTHERAPY; CARCINOMA; PLATINUM; HYSTERECTOMY; DELIVERY;
D O I：
10.1159/000320156
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cervical cancer in pregnancy is an oncologic challenge. Empirical cisplatin is recommended to prevent cancer progression until fetal maturity. Seven patients with cervical cancer in the second trimester decided to delay delivery together with neoadjuvant chemotherapy. After 2-4 cycles, caesarean section and radical hysterectomy were performed above 32 weeks of gestation. Synchronous samples from maternal blood, umbilical cord blood and amniotic fluid were taken. All patients delivered healthy babies. Cisplatin concentrations in umbilical cord and amniotic fluid were 31-65 and 13-42% of the maternal blood, respectively. This is the first series on in vivo cisplatin concentration in the fetomaternal compartment. Copyright (C) 2010 S. Karger AG, Basel
引用
收藏
页码：72 / 77
页数：6
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