Isolation of generator-produced 223Ra in 0.9-% NaCl solutions containing EDTA for direct radiotherapeutic studies

被引：13

作者：

Mokhodoeva, Olga ^{[1
]}

Guseva, Lidiya ^{[1
]}

Dogadkin, Nikolay ^{[1
]}

机构：

[1] Russian Acad Sci, Vernadsky Inst Geochem & Analyt Chem, Moscow 119991, Russia

来源：

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY | 2015年 / 304卷 / 01期

关键词：

Ra-223; Alpha-radiopharmaceuticals; Radioisotope generators; Targeted radiotherapy; METASTATIC PROSTATE-CANCER; SKELETAL METASTASES; BONE METASTASES; ALPHA; RADIUM-223; CHEMISTRY;

D O I：

10.1007/s10967-014-3777-7

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A novel approach to the preparation of the alpha-emitting radionuclide Ra-223 was proposed to be applied for direct treatment of bone metastases and targeted alpha-radioimmunotherapy. The tandem generator system based on ion exchange columns was developed for isolation of Ra-223 in the form of Ra-223-EDTA complexes in 0.9 % NaCl solutions at pH = 7.4-8.0. Advantages of the method for routine laboratory work and clinical implementations are discussed.

引用

页码：449 / 453

页数：5

共 13 条

[1] High-linear energy transfer irradiation targeted to skeletal metastases by the α-emitter 223Ra:: Adjuvant or alternative to conventional modalities? [J].

Bruland, Oyvind S. ;

Nilsson, Sten ;

Fisher, Darrell R. ;

Larsen, Roy H. .

CLINICAL CANCER RESEARCH, 2006, 12 (20) :6250S-6257S

[2] Phase I pharmacokinetic and biodistribution study with escalating doses of 223Ra-dichloride in men with castration-resistant metastatic prostate cancer [J].

Carrasquillo, Jorge A. ;

O'Donoghue, Joseph A. ;

Pandit-Taskar, Neeta ;

Humm, John L. ;

Rathkopf, Dana E. ;

Slovin, Susan F. ;

Williamson, Matthew J. ;

Lacuna, Kristine ;

Aksnes, Anne-Kirsti ;

Larson, Steven M. ;

Scher, Howard I. ;

Morris, Michael J. .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2013, 40 (09) :1384-1393

[3] A tandem generator for produciton and isolation of short-lived α-emitting radionuclides of Ra, Pb, and Bi in EDTA solutions [J].

Guseva L.I. ;

Dogadkin N.N. .

Radiochemistry, 2008, 50 (3) :310-315

[4] An 227Ac-211Pb generator for test experiments of solution chemistry of element 114 [J].

Guseva, LI ;

Tikhomirova, GS ;

Dogadkin, NN .

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, 2004, 260 (01) :167-172

[5]

Harrison Michael R, 2013, Cancer Manag Res, V5, P1, DOI 10.2147/CMAR.S25537

[6]

Henriksen G, 2002, CANCER RES, V62, P3120

[7] 223Ra for endoradiotherapeutic applications prepared from an immobilized 227Ac/227Th source [J].

Henriksen, G ;

Hoff, P ;

Alstad, J ;

Larsen, RH .

RADIOCHIMICA ACTA, 2001, 89 (10) :661-666

[8]

Jadvar H, 2013, CLIN NUCL MED, V38, P966, DOI 10.1097/RLU.0000000000000290

[9]

Larsen RH, 2006, IN VIVO, V20, P325

[10] First clinical experience with α-emitting radium-223 in the treatment of skeletal metastases [J].

Nilsson, S ;

Larsen, RH ;

Fosså, SD ;

Balteskard, L ;

Borch, KW ;

Westlin, JE ;

Salberg, G ;

Bruland, OS .

CLINICAL CANCER RESEARCH, 2005, 11 (12) :4451-4459

← 1 2 →