Role of the ubiquitin-proteasome system in the progression of oral squamous cell carcinoma

被引：0
作者：
Mikhalev, D. E. [1 ]
Baydik, O. D. [1 ]
Kondakova, I., V [2 ]
Sidenko, E. A. [2 ]
Mukhamedov, M. R. [2 ]
Sysolyatin, P. G. [3 ]
机构：
[1] Siberian State Med Univ SSMU, 2 Moscow Trakt, Tomsk 634050, Russia
[2] Russian Acad Sci, Canc Res Inst, Tomsk Natl Res Med Ctr Inriv, 5 Kooperativny Str, Tomsk 634050, Russia
[3] Novosibirsk State Med Univ NSMU, 52 Krasny Av, Novosibirsk 630091, Russia
来源：
BYULLETEN SIBIRSKOY MEDITSINY | 2021年 / 20卷 / 02期
关键词：
ubiquitin-proteasome system; oral squamous cell carcinoma; proteasome; pathogenesis; PROGNOSTIC BIOMARKERS; BREAST-CANCER; GROWTH-FACTOR; REG-GAMMA; EXPRESSION; PA28-GAMMA; CYCLE; HEAD; NECK; MICROPARTICLES;
D O I：
10.20538/1682-0363-2021-2-160-167
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The ubiquitin-proteasome system (UPS) controls the activity, subcellular localization, and stability of many cellular proteins that affect cellular homeostasis by regulating multiple signaling cascades. The activity of this system is associated with the emergence and progression of oral squamous cell carcinoma, since specific proteolysis of most intracellular proteins involved in the pathogenesis of cancer is implemented by this system. The review article presents data on the characteristics of proteasomes and the process of substrate protein ubiquitination. The role of the ubiquitin-proteasome system in the pathogenesis of oral squamous cell carcinoma is shown, and the prospects of its use in precancerous diseases are described. The literature search was carried out in the search engines Medline, eLIBRARY, Scopus, The Cochrane Library, and RSCI.
引用
收藏
页码：160 / 167
页数：8
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