Living with p53, dying of p53

被引：257
作者：
Aylon, Yael [1 ]
Oren, Moshe [1 ]
机构：
[1] Weizmann Inst Sci, Dept Mol Cell Biol, IL-76100 Rehovot, Israel
来源：
CELL | 2007年 / 130卷 / 04期
关键词：
D O I：
10.1016/j.cell.2007.08.005
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The p53 tumor suppressor protein acts as a major defense against cancer. Among its most distinctive features is the ability to elicit both apoptotic death and cell cycle arrest. In this issue of Cell, Das et al. ( 2007) and Tanaka et al. ( 2007) provide new insights into the mechanisms that dictate the life and death decisions of p53.
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收藏
页码：597 / 600
页数：4
相关论文
共 24 条
[1]   Constitutive DNase I hypersensitivity of p53-regulated promoters [J].
Braastad, CD ;
Han, ZY ;
Hendrickson, EA .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (10) :8261-8268
[2]   Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression [J].
Budhram-Mahadeo, Vishwanie S. ;
Bowen, Samantha ;
Lee, Sonia ;
Perez-Sanchez, Christina ;
Ensor, Elizabeth ;
Morris, Peter J. ;
Latchman, David S. .
NUCLEIC ACIDS RESEARCH, 2006, 34 (22) :6640-6652
[3]  
Coutts AS, 2006, BIOCHEM SOC SYMP, V73, P181
[4]  
DAS S, 2007, CELL
[5]   Ser46 phosphorylation regulates p53-dependent apoptosis and replicative senescence [J].
Feng, Lijin ;
Hollstein, Monica ;
Xu, Yang .
CELL CYCLE, 2006, 5 (23) :2812-2819
[6]   Classic and novel roles of p53:: prospects for anticancer therapy [J].
Fuster, Jose J. ;
Sanz-Gonzalez, Silvia M. ;
Moll, Ute M. ;
Andres, Vicente .
TRENDS IN MOLECULAR MEDICINE, 2007, 13 (05) :192-199
[7]   The p53 pathway: positive and negative feedback loops [J].
Harris, SL ;
Levine, AJ .
ONCOGENE, 2005, 24 (17) :2899-2908
[8]   Y-box factor YB1 controls p53 apoptotic function [J].
Homer, C ;
Knight, DA ;
Hananeia, L ;
Sheard, P ;
Risk, J ;
Lasham, A ;
Royds, JA ;
Braithwaite, AW .
ONCOGENE, 2005, 24 (56) :8314-8325
[9]   Phosphorylation of CBP by IKKα promotes cell growth by switching the binding preference of CBP from p53 to NF-κB [J].
Huang, Wei-Chien ;
Ju, Tsai-Kai ;
Hung, Mien-Chie ;
Chen, Ching-Chow .
MOLECULAR CELL, 2007, 26 (01) :75-87
[10]   Differential transactivation by the p53 transcription factor is highly dependent on p53 level and promoter target sequence [J].
Inga, A ;
Storici, F ;
Darden, TA ;
Resnick, MA .
MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (24) :8612-8625
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