Synthesis, cytotoxicity, DNA interaction and cell cycle studies of trans-diiodophosphine Pt(II) complexes

被引：13
作者：
Medrano, Angeles [1 ]
Dennis, Stephen M. [2 ]
Alvarez-Valdes, Amparo [1 ]
Perles, Josefina [3 ]
Mason, Tracey McGregor [2 ]
Quiroga, Adoracion G. [1 ]
机构：
[1] Univ Autonoma Madrid, Dept Inorgan Chem, E-28049 Madrid, Spain
[2] Stevenson Univ, Dept Chem, Stevenson, MD 21153 USA
[3] Univ Autonoma Madrid, SIDI, E-28049 Madrid, Spain
来源：
DALTON TRANSACTIONS | 2015年 / 44卷 / 08期
关键词：
PLATINUM COMPLEXES; CISPLATIN; LIGANDS; DRUGS; CANCER; PHOSPHINES; RESISTANCE; APOPTOSIS; AMINES;
D O I：
10.1039/c4dt02392g
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Platinum complexes, bearing aliphatic amines and phosphine ligands in trans configuration with iodide as leaving groups, are synthesized and characterized. The crystal structure of trans-PtI2(isopropylamine)-(PPh3) is reported. The complex bearing isopropylamine is demonstrated to be the best candidate as its cytotoxic activity is comparable to or better than cisplatin. A remarkably higher interaction of the complexes with DNA is reported as compared to the parent chlorido series. Cell cycle studies of the complexes in six human cell lines are performed and also compared with the previous series.
引用
收藏
页码：3557 / 3562
页数：6
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