Lack of association of glutathione s-transferase (GSTM1 and GSTT1) polymorphisms with susceptibility of osteoporosis

Osteoporosis is a skeletal disorder characterized by low bone mineral density (BMD). Several studies have been suggested that some of the genetic factors may be contributed to osteoporosis by specific polymorphisms. The aim of the present study was to evaluate relationship between the glutathione s-transferase (GSTM1 and GSTT1) gene polymorphisms and osteoporosis. To explore this possible association, polymorphisms of GSTM1 and GSTT1 genes were tested in in 79 osteoporosis patients and 53 healthy control subjects. The distributions of polymorphisms of GSTM1 and GSTT1 genes between the osteoporosis group and the control group were similar. The difference in distributions of polymorphisms of GSTM1 and GSTT1 genes did not show any association with susceptibility of osteoporosis (GSTM1, OR= 0.858, 95% CI= 0.403-1.827, p= 0.691; GSTT1, OR= 1.491, 95% CI= 0.706-3.145, p= 0.395). Our results suggested that GSTM1 and GSTT1 polymorphisms are not associated with susceptibility of osteoporosis in Korean population.