Serum Mac-2-binding protein glycosylation isomer and risk of hepatocellular carcinoma in entecavir-treated chronic hepatitis B patients

被引:14
作者
Mak, Lung-Yi [1 ]
Ko, Michael [1 ]
To, Elvis [1 ]
Wong, Danny Ka-Ho [1 ,2 ]
Ma, Justin Hei-Chun [1 ]
Hui, Teresa Lok-Yee [1 ]
Seto, Wai-Kay [1 ,2 ]
Fung, James [1 ,2 ]
Lai, Ching-Lung [1 ,2 ]
Yuen, Man-Fung [1 ,2 ]
机构
[1] Univ Hong Kong, Queen Mary Hosp, Dept Med, Pokfulam Rd 102, Hong Kong, Peoples R China
[2] Univ Hong Kong, State Key Lab Liver Res, Hong Kong, Peoples R China
关键词
biomarker; chronic hepatitis B; entecavir; hepatocellular carcinoma; M2BPGi; MAC-2; BINDING-PROTEIN; TENOFOVIR DISOPROXIL FUMARATE; GALECTIN-3; EXPRESSION; LIVER FIBROSIS; CIRRHOSIS; PREDICTS; LEVEL;
D O I
10.1111/jgh.14637
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background and Aim Hepatocellular carcinoma (HCC) can still develop in chronic hepatitis B (CHB) patients receiving antiviral treatment. Serum Mac-2-binding protein glycosylation isomer (M2BPGi) is a novel marker for liver fibrosis. We investigated its role on incidence of HCC in entecavir (ETV)-treated CHB patients. Methods We identified HCC cases diagnosed at >= 1 year of ETV treatment. CHB patients without HCC (matched for age, gender, baseline hepatitis B virus-DNA, and duration of ETV treatment) were identified in approximately 1:2 ratio (HCC: non-HCC) for comparison. Serum samples were retrieved at baseline (initiation of ETV), 3, and 5 years of ETV for serum M2BPGi measurement (expressed in cut-off index [COI]). Results One hundred HCC cases were matched with 185 CHB patients without HCC (median age 56.7 years, 78.9% male, baseline hepatitis B virus-DNA 5.6 logIU/mL, and median follow-up 7.1 years). Median time from ETV initiation to incident HCC was 3.9 years. Serum M2BPGi levels were significantly higher in HCC cases compared with controls at baseline and year 3 (1.25 vs 0.98 [P = 0.004], 0.89 vs 0.74 [P = 0.018] COI, respectively). Multivariate analysis showed that baseline M2BPGi was the only independent factor associated with incident HCC (odds ratio 1.241, 95% confidence interval 1.039-1.482, P = 0.017). Using a cut-off value of 1.15 COI, the sensitivity, specificity, positive predictive value, and negative predictive value of baseline serum M2BPGi in cirrhotic patients to predict incident HCC were 90%, 53.8%, 69.6%, and 82.1%, respectively. Conclusions Baseline and 3-year serum M2BPGi may be useful to identify high risk patients on antiviral treatment for subsequent HCC development.
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页码:1817 / 1823
页数:7
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