Synthesis and Anti-tumor Activity Evaluation of Alkyl Heterocyclyl Disulfides

被引：4

作者：

Gong, Jingxu ^{[1
]}

Sheng, Li ^{[1
]}

Yao, Ligong ^{[1
]}

Li, Jia ^{[1
]}

Zhou, Yubo ^{[1
]}

Guo, Yuewei ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 32卷 / 03期

关键词：

disulfides; synthesis; anti-tumor activity; ONE-POT SYNTHESIS; MACROCYCLIC POLYDISULFIDE; GYMNORRHIZOL;

D O I：

10.6023/cjoc1101201

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of alkyl heterocyclyl disulfides were prepared by reaction of the heterocyclyl thiol with Bunte salts. All the synthesized compounds showed interesting inhibit activities toward human colon carcinoma cells (HCT-116) in vitro. The IC50 values of the tested compounds ranged from 4.8 mu g.mL(-1) to 17.7 mu g.mL(-1).

引用

页码：593 / 596

页数：4

共 23 条

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