The impact of pneumococcal conjugate vaccines on otitis media - Can we extrapolate to pneumonia?

被引：2
作者：
Dagan, Ron [1 ]
机构：
[1] Ben Gurion Univ Negev, Soroka Univ Med Ctr, Pediat Infect Dis Unit, IL-84101 Beer Sheva, Israel
来源：
VACCINE | 2008年 / 26卷
关键词：
otitis; vaccine; antibody;
D O I：
10.1016/j.vaccine.2008.05.019
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Pneumococcal conjugate vaccines (PCVs) have significant efficacy in preventing acute otitis media caused by vaccine-type pneumococcal serotypes. This article questions whether experiences with pneumococcal otitis can be applied to pneumococcal pneumonia, and examines whether PCVs have a class effect, meaning do different PCVs offer equivalent protection against the same outcome of pneumococcal disease. While PCVs appear to have a class effect in general, variability in serotype-specific antibody concentrations makes extrapolation from one vaccine to another difficult. Antibody concentrations or measurements of antibody functionality may provide a means to anticipate a predicted outcome in pneumococcal pneumonia for certain emergent vaccine candidates. (c) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：B16 / B18
页数：3
相关论文
共 13 条
[1]   Microbiology of otitis media in Costa Rican children, 1999 through 2001 [J].
Arguedas, A ;
Dagan, R ;
Soley, C ;
Loaiza, C ;
Knudsen, K ;
Porat, N ;
Pérez, A ;
Brilla, E ;
Herrera, ML .
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2003, 22 (12) :1063-1068
[2]  
BLUESTONE CD, 1995, OTITIS MEDIA INFANTS, P145
[3]   INFLUENZA-A VIRUS-INDUCED ACUTE OTITIS-MEDIA [J].
BUCHMAN, CA ;
DOYLE, WJ ;
SKONER, DP ;
POST, JC ;
ALPER, CM ;
SEROKY, JT ;
ANDERSON, K ;
PRESTON, RA ;
HAYDEN, FG ;
FIREMAN, P ;
EHRLICH, GD .
JOURNAL OF INFECTIOUS DISEASES, 1995, 172 (05) :1348-1351
[4]   Efficacy of a pneumococcal conjugate vaccine against acute otitis media [J].
Eskola, J ;
Kilpi, T ;
Palmu, A ;
Jokinen, J ;
Haapakoski, J ;
Herva, E ;
Takala, A ;
Käyhty, H ;
Karma, P ;
Kohberger, R ;
Siber, G ;
Mäkela, PH ;
Lockhart, S ;
Ecrola, M .
NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (06) :403-409
[5]   Identification of biofilm proteins in non-typeable Haemophilus Influenzae [J].
Gallaher, Timothy K. ;
Wu, Siva ;
Webster, Paul ;
Aguilera, Rodrigo .
BMC MICROBIOLOGY, 2006, 6 (1)
[6]   Direct detection of bacterial Biofilms on the middle-ear mucosa of children with chronic otitis media [J].
Hall-Stoodley, Luanne ;
Hu, Fen Ze ;
Gieseke, Armin ;
Nistico, Laura ;
Nguyen, Duc ;
Hayes, Jay ;
Forbes, Michael ;
Greenberg, David P. ;
Dice, Bethany ;
Burrows, Amy ;
Wackym, P. Ashley ;
Stoodley, Paul ;
Post, J. Christopher ;
Ehrlich, Garth D. ;
Kerschner, Joseph E. .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2006, 296 (02) :202-211
[7]   Role of sialic acid and complex carbohydrate biosynthesis in Biofilm formation by nontypeable Haemophilus influenzae in the chinchilla middle ear [J].
Jurcisek, J ;
Greiner, L ;
Watanabe, H ;
Zaleski, A ;
Apicella, MA ;
Bakaletz, LO .
INFECTION AND IMMUNITY, 2005, 73 (06) :3210-3218
[8]   Biofilms formed by nontypeable Haemophilus influenzae in vivo contain both double-stranded DNA and type IV pilin protein [J].
Jurcisek, Joseph A. ;
Bakaletz, Lauren O. .
JOURNAL OF BACTERIOLOGY, 2007, 189 (10) :3868-3875
[9]   Protective efficacy of a second pneumococcal conjugate vaccine against pneumococcal acute otitis media in infants and children:: Randomized, controlled trial of a 7-valent pneumococcal polysaccharide-meningococcal outer membrane protein complex conjugate vaccine in 1666 children [J].
Kilpi, T ;
Åhman, H ;
Jokinen, J ;
Lankinen, KS ;
Palmu, A ;
Savolainen, H ;
Grönholm, M ;
Leinonen, M ;
Hovi, T ;
Eskola, J ;
Käyhty, H ;
Bohidar, N ;
Sadoff, JC ;
Mäkelä, PH .
CLINICAL INFECTIOUS DISEASES, 2003, 37 (09) :1155-1164
[10]   Biofilm formation by nontypeable Haemophilus influenzae: strain variability, outer membrane antigen expression and role of pili [J].
Murphy, Timothy F. ;
Kirkham, Charmaine .
BMC MICROBIOLOGY, 2002, 2 (1) :1-8
12