A New Acetylenic Compound and Other Bioactive Metabolites from a Shark Gill-derived Penicillium Strain

被引：0

作者：

Zhang, Yi ^{[1
,2
,3
]}

Feng, Yan ^{[1
]}

Kramer, Markus ^{[3
]}

Essmann, Frank ^{[4
]}

Grond, Stephanie ^{[3
]}

机构：

[1] Guangdong Ocean Univ GDOU, Guangdong Prov Key Lab Aquat Prod Proc & Safety, Analyt & Testing Ctr GDOU,Coll Food Sci & Technol, Zhanjiang Key Lab Brain Hlth Related Marine Drugs, Zhanjiang 524088, Peoples R China

[2] Dalian Univ Technol, Sch Life Sci & Technol, Dalian 116024, Peoples R China

[3] Univ Tubingen, Inst Organ Chem, D-72076 Tubingen, Germany

[4] Univ Tubingen, Interfac Inst Biochem, D-72076 Tubingen, Germany

来源：

RECORDS OF NATURAL PRODUCTS | 2017年 / 11卷 / 01期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

Secondary metabolites; shark; Penicillium polonicum; bioactivity; FUNGUS; ALKALOIDS; ANTIFUNGAL;

D O I：

暂无

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Nine chiral compounds (1-9) were isolated from the static fermentation culture of a shark gill-derived fungus Penicillium polonicum AP2T1. These compounds include a new acetylenic aromatic ether (1, (-)-WA), four alkaloids (aurantiomide C (2), fructigenine A (3), cyclopenin (4) and cyclopenol (5)) and four oxygenated compounds ((R)-penipratynolene (6), (3S,4S)-3,4-dihydro-3,4,8-trihydroxyl-naphthalenone (7), verrucosidin (8) and norverrucosidin (9)). Their structures were elucidated by MS, NMR, optical rotation and circular dichroism (CD). In antimicrobial tests, compounds 1-4, 6 and 8-9 showed weak antibacterial activity against Staphylococcus aureus, Bacillus subtilis, and/or Escherichia coli. Compounds 3, 8 and 9 also exhibited moderate toxicity against Artemia salina larva, and showed cytotoxicity against human colon cancer cell line HCT116.

引用

页码：31 / 36

页数：6

共 21 条

[1] ANACINE, A NEW BENZODIAZEPINE METABOLITE OF PENICILLIUM-AURANTIOGRISEUM PRODUCED WITH OTHER ALKALOIDS IN SUBMERGED FERMENTATION [J].