Botulinum toxin therapy for temporomandibular joint disorders: a systematic review of randomized controlled trials

被引：43

作者：

Chen, Y. -W. ^{[1
,2
,3
,4
,5
]}

Chiu, Y. -W. ^{[1
]}

Chen, C. -Y. ^{[2
,6
]}

Chuang, S. -K. ^{[4
,5
]}

机构：

[1] Taipei Vet Gen Hosp, Dept Stomatol, Taipei, Taiwan

[2] Natl Yang Ming Univ, Sch Dent, Taipei 112, Taiwan

[3] Natl Yang Ming Univ, Inst Clin Med, Taipei 112, Taiwan

[4] Massachusetts Gen Hosp, Dept Oral & Maxillofacial Surg, Boston, MA 02114 USA

[5] Harvard Univ, Sch Dent Med, Boston, MA 02114 USA

[6] Univ Maryland, Sch Dent, Dept Pediat Dent, Baltimore, MD 21201 USA

来源：

INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY | 2015年 / 44卷 / 08期

关键词：

botulinum toxin; clinical trials; efficacy; myofascial pain; review; temporomandibular joint; MYOFASCIAL PAIN; INJECTION;

D O I：

10.1016/j.ijom.2015.04.003

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

The objective of this study was to undertake a systematic review to assess the efficacy of botulinum toxin therapy (BTX) for temporomandibular joint disorders (TMDs). A comprehensive search of major databases through PubMed, EMBASE, and Cochrane CENTRAL was conducted to locate all relevant articles published from inception to October 2014. Eligible studies were selected based on inclusion criteria and included English language, peer-reviewed publications of randomized controlled trials comparing BTX versus any alternative intervention or placebo. Quality assessment and data extraction were done according to the Cochrane risk of bias tool and recommendations. The entire systematic search and selection process was done independently by two reviewers. Five relevant study trials were identified, involving 117 participants. Two trials revealed a significant between-group difference in myofascial pain reduction, another trial that compared BTX with fascial manipulation showed equal efficacy of pain relief on TMDs, while the remaining two trials showed no significant difference between the BTX and placebo groups. Because of considerable variations in study methods and evaluation of results, a meta-analysis could not be performed. Based on this review, no consensus could be reached on the therapeutic benefits of BTX on TMDs. A more rigorous design of trials should be carried out in future studies.

引用

页码：1018 / 1026

页数：9

共 33 条

[1] Hypothesis on a cause of temporomandibular joint disorders [J].

Abenavoli, FM .

PLASTIC AND RECONSTRUCTIVE SURGERY, 2003, 111 (07) :2473-2474

[2]

Al-Jundi MA, 2008, J OROFAC PAIN, V22, P97

[3]

[Anonymous], J ORAL MAXILLOFAC SU

[4] Botulinum toxin therapy for pain and inflammatory disorders: mechanisms and therapeutic effects [J].

Borodic, GE ;

Acquadro, M ;

Johnson, EA .

EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2001, 10 (08) :1531-1544

[5]

Buescher JJ, 2007, AM FAM PHYSICIAN, V76, P1477

[6] BOTULINUM TOXIN IN THE TREATMENT OF MYOFASCIAL PAIN SYNDROME [J].

CHESHIRE, WP ;

ABASHIAN, SW ;

MANN, JD .

PAIN, 1994, 59 (01) :65-69

[7]

Clark Glenn T, 2007, Dent Clin North Am, V51, P245, DOI 10.1016/j.cden.2006.09.003

[8]

Colhado Orlando Carlos Gomes, 2009, Rev. Bras. Anestesiol., V59, P366, DOI 10.1590/S0034-70942009000300013

[9]

Dworkin Samuel F., 1992, Journal of Craniomandibular Disorders, V6, P301

[10]

Ernberg M, 2011, PAIN, V152, P1988, DOI 10.1016/j.pain.2011.03.036

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