Rapamycin reduces clinical signs and neuropathic pain in a chronic model of experimental autoimmune encephalomyelitis

被引：50

作者：

Lisi, L. ^{[1
]}

Navarra, P. ^{[1
]}

Cirocchi, R. ^{[1
]}

Sharp, A. ^{[2
]}

Stigliano, E. ^{[3
]}

Feinstein, D. L. ^{[2
]}

Dello Russo, C. ^{[1
]}

机构：

[1] Univ Cattolica Sacro Cuore, Sch Med, Inst Pharmacol, I-00168 Rome, Italy

[2] Univ Illinois, Dept Anesthesiol, Chicago, IL USA

[3] Univ Cattolica Sacro Cuore, Sch Med, Inst Pathol Anat, I-00168 Rome, Italy

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2012年 / 243卷 / 1-2期

关键词：

mTOR; Rapamycin; EAE; Neuropathic pain; Progressive MS; Myelin; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; MULTIPLE-SCLEROSIS; MAMMALIAN TARGET; TUBEROUS SCLEROSIS; T-CELL; MTOR; SIROLIMUS; PATHWAY; DIFFERENTIATION; ACTIVATION;

D O I：

10.1016/j.jneuroim.2011.12.018

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Current treatments used in Multiple Sclerosis (MS) are partly effective in the early stages of the disease but display very limited benefits in patients affected by progressive MS. One possible explanation is that these therapies are unable to target the inflammatory component most active during the progressive phase of the disease, and compartmentalized behind the blood-brain barrier. Our findings show that Rapamycin ameliorates clinical and histological signs of chronic EAE when administered during ongoing disease. Moreover, Rapamycin significantly reduced the hyperalgesia observed before clinical development of EAE which, in turn, is completely abolished by the administration of the drug. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：43 / 51

页数：9

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