Expression and clinicopathological significance of the lncRNA HOXA11-AS in colorectal cancer

被引：50
作者：
Li, Tong [1 ]
Xu, Chengfei [1 ]
Cai, Bin [1 ]
Zhang, Meng [1 ]
Gao, Feng [1 ]
Gan, Jialiang [1 ]
机构：
[1] Guangxi Med Univ, Dept Colorectal & Anal Surg, Affiliated Hosp 1, 6 Shuangyong Rd, Nanning 530021, Nanning, Peoples R China
来源：
ONCOLOGY LETTERS | 2016年 / 12卷 / 05期
关键词：
biomarker; colorectal cancer; HOXA11-AS; long non-coding RNA; LONG NONCODING RNA; POOR-PROGNOSIS; EVOLUTION;
D O I：
10.3892/ol.2016.5129
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
HOXA11 antisense RNA (HOXA11-AS) is a long non-coding RNA (lncRNA) that is important in determining cancer progression. HOXA11-AS was recently identified as a novel biomarker in lung cancer progression. However, its role in colorectal cancer (CRC) remains poorly understood. The present study aimed to analyze lncRNA HOXA11-AS expression in CRC and investigate a possible association between HOXA11-AS and clinicopathological factors. HOXA11-AS expression was examined by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) in 84 CRC tissues and adjacent non-cancerous tissues, in addition to 3 CRC cell lines and 1 human normal colorectal cell line. The results demonstrated that HOXA11-AS expression was decreased in the CRC tissues and cell lines compared with that of the controls (P<0.05). Clinicopathological analysis indicated that low HOXA11-AS expression was significantly correlated with tumor size, advanced tumor-node-metastasis stage, lymph node metastasis and carcinoembryonic antigen level of patients with CRC (P<0.05). Furthermore, the areas under the curve (AUC) were 0.613 and 0.628 for HOXA11-AS, indicating that the lncRNA is able to distinguish CRC tissue from non-cancerous tissue, and CRC tissue with lymph node metastasis from CRC without lymph node metastasis. Therefore, HOXA11-AS may function as a potential biomarker and target for novel therapeutic strategies to treat CRC.
引用
收藏
页码：4155 / 4160
页数：6
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